{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jangi S"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","Tufts University School of Medicine","National Institutes of Health"],"pagination":["821-830.e7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10960711"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(4)"],"pubmed_abstract":["<h4>Background & aims</h4>Intestinal fungi have been implicated in the pathogenesis of ulcerative colitis (UC). However, it remains unclear if fungal composition is altered during active versus quiescent disease.<h4>Methods</h4>We analyzed clinical and metagenomic data from the Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD), available via the IBD Plexus Program of the Crohn's & Colitis Foundation. We evaluated the fungal composition of fecal samples from 421 patients with UC during clinical activity and remission. Within a longitudinal subcohort (n = 52), we assessed for dynamic taxonomic changes across alterations in clinical activity over time. We examined if fungal amplicon sequence variants and fungal-bacterial relationships were altered during activity versus remission. Finally, we classified activity in UC using a supervised machine learning random forest model trained on fungal abundance data.<h4>Results</h4>During clinical activity, the relative abundance of genus Candida was increased 3.5-fold (P-adj < 1 × 10<sup>-4</sup>) compared with during remission. Patients with longitudinal reductions in clinical activity demonstrated parallel reductions in Candida relative abundance (P < .05). Candida relative abundance correlated with Parabacteroides diastonis, Faecalibacterium prausnitzii, and Bacteroides dorei relative abundance (P < .05) during remission; however, these correlations were disrupted during activity. Fungal abundance data successfully classified patients with active or quiescent UC (area under the curve ∼0.80), with Candida relative abundance critical to the success of the model.<h4>Conclusions</h4>Clinical activity in UC is associated with an increased relative abundance of Candida, cross-sectionally and dynamically over time. The role of fecal Candida as a target for therapeutics in UC should be evaluated."],"journal":["Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association"],"pubmed_title":["Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis."],"pmcid":["PMC10960711"],"funding_grant_id":["KL2TR002545","KL2 TR002545"],"pubmed_authors":["Friedman S","Zhao N","Michaud DS","Hsia K","Singh S","Jangi S","Kumamoto CA"],"additional_accession":[]},"is_claimable":false,"name":"Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis.","description":"<h4>Background & aims</h4>Intestinal fungi have been implicated in the pathogenesis of ulcerative colitis (UC). However, it remains unclear if fungal composition is altered during active versus quiescent disease.<h4>Methods</h4>We analyzed clinical and metagenomic data from the Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD), available via the IBD Plexus Program of the Crohn's & Colitis Foundation. We evaluated the fungal composition of fecal samples from 421 patients with UC during clinical activity and remission. Within a longitudinal subcohort (n = 52), we assessed for dynamic taxonomic changes across alterations in clinical activity over time. We examined if fungal amplicon sequence variants and fungal-bacterial relationships were altered during activity versus remission. Finally, we classified activity in UC using a supervised machine learning random forest model trained on fungal abundance data.<h4>Results</h4>During clinical activity, the relative abundance of genus Candida was increased 3.5-fold (P-adj < 1 × 10<sup>-4</sup>) compared with during remission. Patients with longitudinal reductions in clinical activity demonstrated parallel reductions in Candida relative abundance (P < .05). Candida relative abundance correlated with Parabacteroides diastonis, Faecalibacterium prausnitzii, and Bacteroides dorei relative abundance (P < .05) during remission; however, these correlations were disrupted during activity. Fungal abundance data successfully classified patients with active or quiescent UC (area under the curve ∼0.80), with Candida relative abundance critical to the success of the model.<h4>Conclusions</h4>Clinical activity in UC is associated with an increased relative abundance of Candida, cross-sectionally and dynamically over time. The role of fecal Candida as a target for therapeutics in UC should be evaluated.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-07-11T03:03:47.699Z","creation":"2025-07-11T03:03:47.699Z"},"accession":"S-EPMC10960711","cross_references":{"pubmed":["37802272"],"doi":["10.1016/j.cgh.2023.09.023"]}}