biostudies-literatureUnknown46(2)Alves CUniversidade de CoimbraTecnimede, SA<h4>Background</h4>Ibandronate is effective in reducing the risk of vertebral fractures, but experimental evidence offers conflicting results regarding nonvertebral fractures. Real-world evidence has been published evaluating the anti-nonvertebral fracture effect of ibandronate.<h4>Aim</h4>This meta-analysis of observational studies assessed the effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis.<h4>Method</h4>Pubmed/Embase databases were searched for observational studies. Risks of nonvertebral fractures and hip fractures were the outcomes. Meta-analyses were performed pooling rate ratios (RRs), using random-effects models. Data were reanalysed in sensitivity analyses considering Knapp-Hartung method and Bayesian random-effects.<h4>ResulInternational journal of clinical pharmacy357-367https://www.ebi.ac.uk/biostudies/studies/S-EPMC10960777biostudies-literatureThe effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis: systematic review and meta-analysis of observational studies.PMC10960777Penedones AAlves CBatel-Marques FMendes DOliveira TDonato AfalseThe effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis: systematic review and meta-analysis of observational studies.<h4>Background</h4>Ibandronate is effective in reducing the risk of vertebral fractures, but experimental evidence offers conflicting results regarding nonvertebral fractures. Real-world evidence has been published evaluating the anti-nonvertebral fracture effect of ibandronate.<h4>Aim</h4>This meta-analysis of observational studies assessed the effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis.<h4>Method</h4>Pubmed/Embase databases were searched for observational studies. Risks of nonvertebral fractures and hip fractures were the outcomes. Meta-analyses were performed pooling rate ratios (RRs), using random-effects models. Data were reanalysed in sensitivity analyses considering Knapp-Hartung method and Bayesian random-effects.<h4>Resul2024-01-01T00:00:00Z2024 Apr2026-07-15T20:04:54.419Z2026-07-09T03:10:17.388ZS-EPMC109607773811289010.1007/s11096-023-01666-x