{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Storm KS"],"funding":["Copenhagen University"],"pubmed_abstract":["<h4>Background</h4>Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition of large planning margins to the radiation field to ensure target coverage regardless of the considerable organ motion in the pelvic region. This increases the irradiated volume and radiation dose to the surrounding normal tissue and thereby toxicity. Online adaptive radiotherapy uses artificial intelligence to adjust the treatment to the anatomy of the day. This allows for the reduction of planning margins, minimizing the irradiated volume and thereby radiation to the surrounding normal tissue.This st"],"journal":["BMC cancer"],"pagination":["374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10962183"],"repository":["biostudies-literature"],"pubmed_title":["ROAR-A: re-optimization based Online Adaptive Radiotherapy of anal cancer, a prospective phase II trial protocol."],"pmcid":["PMC10962183"],"pubmed_authors":["Serup-Hansen E","Sibolt P","Persson GF","Astrom LM","Storm KS","Behrens CP"],"additional_accession":[]},"is_claimable":false,"name":"ROAR-A: re-optimization based Online Adaptive Radiotherapy of anal cancer, a prospective phase II trial protocol.","description":"<h4>Background</h4>Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition of large planning margins to the radiation field to ensure target coverage regardless of the considerable organ motion in the pelvic region. This increases the irradiated volume and radiation dose to the surrounding normal tissue and thereby toxicity. Online adaptive radiotherapy uses artificial intelligence to adjust the treatment to the anatomy of the day. This allows for the reduction of planning margins, minimizing the irradiated volume and thereby radiation to the surrounding normal tissue.This st","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T14:54:29.813Z","creation":"2026-07-06T03:09:04.958Z"},"accession":"S-EPMC10962183","cross_references":{"pubmed":["38528456"],"doi":["10.1186/s12885-024-12111-1"]}}