{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu X"],"funding":["Yunnan Fundamental Research Projects","Kunming University of Science and Technology & People's hospital of Lijiang Joint Special Project on Medical Research","Natural Science Foundation of Yunnan Province","National Natural Science Foundation of China","Kunming University of Science and Technology & The second people's hospital of Yuxi Joint Special Project on Medical Research"],"pagination":["e14690"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10964037"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(3)"],"pubmed_abstract":["<h4>Introduction</h4>Electroconvulsive therapy (ECT) is widely used for treatment-resistant depression. However, it is unclear whether/how ECT can be targeted to affect brain regions and circuits in the brain to dynamically regulate mood and cognition.<h4>Methods</h4>This study used brain entropy (BEN) to measure the irregular levels of brain systems in 46 major depressive disorder (MDD) patients before and after ECT treatment. Functional connectivity (FC) was further adopted to reveal changes of functional couplings. Moreover, transcriptomic and neurotransmitter receptor data were used to reveal genetic and molecular basis of the changes of BEN and functional connectivities.<h4>Results</h4>Compared to pretreatment, the BEN in the posterior cerebellar lobe (PCL) significantly decreased and"],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy."],"pmcid":["PMC10964037"],"funding_grant_id":["KUST-YX2022001","KUST-YX2022003","202201BE070001-004","62176044","202102AA100053","KUST-LJ2022002Y"],"pubmed_authors":["Bai T","Cai D","Chen K","Zhang X","Tian Y","Ma Y","Wang J","Yu X","Wang K","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy.","description":"<h4>Introduction</h4>Electroconvulsive therapy (ECT) is widely used for treatment-resistant depression. However, it is unclear whether/how ECT can be targeted to affect brain regions and circuits in the brain to dynamically regulate mood and cognition.<h4>Methods</h4>This study used brain entropy (BEN) to measure the irregular levels of brain systems in 46 major depressive disorder (MDD) patients before and after ECT treatment. Functional connectivity (FC) was further adopted to reveal changes of functional couplings. Moreover, transcriptomic and neurotransmitter receptor data were used to reveal genetic and molecular basis of the changes of BEN and functional connectivities.<h4>Results</h4>Compared to pretreatment, the BEN in the posterior cerebellar lobe (PCL) significantly decreased and","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-27T03:53:13.691Z","creation":"2025-04-06T19:02:32.988Z"},"accession":"S-EPMC10964037","cross_references":{"pubmed":["38529527"],"doi":["10.1111/cns.14690"]}}