{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Utsumi H"],"funding":["Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences","Japan Society for the Promotion of Science"],"pagination":["1375655"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10964716"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may cause such contacts to be temporarily weakened, risking improper development and maintenance of tissues. Despite such risks, tissues form properly during normal development. However, it is not well understood whether mitotic abnormalities affect tissue formation. Here, analysis of zebrafish embryos with aberrant mitosis shows that proper progression of mitosis is important to maintain cell contact in developing tissues. By screening mutants with abnormal trunk and tail development, we obtained a mutant with perturbed expression of some tissue-s"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["Deficiency of <i>mastl</i>, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos."],"pmcid":["PMC10964716"],"funding_grant_id":["18H02454 21H02498 19H04797 22H05642 20H01001 23H04930","23EXC203 23EXC601"],"pubmed_authors":["Utsumi H","Takada S","Koshida S","Yabe T","Yamashita A"],"additional_accession":[]},"is_claimable":false,"name":"Deficiency of <i>mastl</i>, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos.","description":"To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may cause such contacts to be temporarily weakened, risking improper development and maintenance of tissues. Despite such risks, tissues form properly during normal development. However, it is not well understood whether mitotic abnormalities affect tissue formation. Here, analysis of zebrafish embryos with aberrant mitosis shows that proper progression of mitosis is important to maintain cell contact in developing tissues. By screening mutants with abnormal trunk and tail development, we obtained a mutant with perturbed expression of some tissue-s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-08T19:54:25.448Z","creation":"2026-04-08T14:34:08.543Z"},"accession":"S-EPMC10964716","cross_references":{"pubmed":["38533088"],"doi":["10.3389/fcell.2024.1375655"]}}