{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao J"],"funding":["NIEHS NIH HHS","National Institutes of Health","University of Louisville School of Medicine","NIGMS NIH HHS","NIH HHS"],"pagination":["210-220"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10964747"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["198(2)"],"pubmed_abstract":["Microplastics (MP) derived from the weathering of polymers, or synthesized in this size range, have become widespread environmental contaminants and have found their way into water supplies and the food chain. Despite this awareness, little is known about the health consequences of MP ingestion. We have previously shown that the consumption of polystyrene (PS) beads was associated with intestinal dysbiosis and diabetes and obesity in mice. To further evaluate the systemic metabolic effects of PS on the gut-liver-adipose tissue axis, we supplied C57BL/6J mice with normal water or that containing 2 sizes of PS beads (0.5 and 5 µm) at a concentration of 1 µg/ml. After 13 weeks, we evaluated indices of metabolism and liver function. As observed previously, mice drinking the PS-containing water had a potentiated weight gain and adipose expansion. Here we found that this was associated with an increased abundance of adipose F4/80+ macrophages. These exposures did not cause nonalcoholic fatty liver disease but were associated with decreased liver:body weight ratios and an enrichment in hepatic farnesoid X receptor and liver X receptor signaling. PS also increased hepatic cholesterol and altered both hepatic and cecal bile acids. Mice consuming PS beads and treated with the berry anthocyanin, delphinidin, demonstrated an attenuated weight gain compared with those mice receiving a control intervention and also exhibited a downregulation of cyclic adenosine monophosphate (cAMP) and peroxisome proliferator-activated receptor (PPAR) signaling pathways. This study highlights the obesogenic role of PS in perturbing the gut-liver-adipose axis and altering nuclear receptor signaling and intermediary metabolism. Dietary interventions may limit the adverse metabolic effects of PS consumption."],"journal":["Toxicological sciences : an official journal of the Society of Toxicology"],"pubmed_title":["Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis."],"pmcid":["PMC10964747"],"funding_grant_id":["R01ES032189","GM127607","P20 GM113226","G7016","P20GM113226","P30ES030283","R01ES019217","P30 ES030283","5P50AA024337","P30 GM127607","T32ES011564","S10 OD020106","R35ES028373","G7021","P42 ES023716","P42ES023716"],"pubmed_authors":["Gomes D","Ekuban A","Rouchka EC","Xu R","O'Toole TE","Adiele N","Malovichko M","Smith ML","Luo J","Zhang X","Gondim DD","Conklin DJ","Banerjee M","Gripshover T","Watson WH","Zhao J","Cave MC"],"additional_accession":[]},"is_claimable":false,"name":"Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis.","description":"Microplastics (MP) derived from the weathering of polymers, or synthesized in this size range, have become widespread environmental contaminants and have found their way into water supplies and the food chain. Despite this awareness, little is known about the health consequences of MP ingestion. We have previously shown that the consumption of polystyrene (PS) beads was associated with intestinal dysbiosis and diabetes and obesity in mice. To further evaluate the systemic metabolic effects of PS on the gut-liver-adipose tissue axis, we supplied C57BL/6J mice with normal water or that containing 2 sizes of PS beads (0.5 and 5 µm) at a concentration of 1 µg/ml. After 13 weeks, we evaluated indices of metabolism and liver function. As observed previously, mice drinking the PS-containing water had a potentiated weight gain and adipose expansion. Here we found that this was associated with an increased abundance of adipose F4/80+ macrophages. These exposures did not cause nonalcoholic fatty liver disease but were associated with decreased liver:body weight ratios and an enrichment in hepatic farnesoid X receptor and liver X receptor signaling. PS also increased hepatic cholesterol and altered both hepatic and cecal bile acids. Mice consuming PS beads and treated with the berry anthocyanin, delphinidin, demonstrated an attenuated weight gain compared with those mice receiving a control intervention and also exhibited a downregulation of cyclic adenosine monophosphate (cAMP) and peroxisome proliferator-activated receptor (PPAR) signaling pathways. This study highlights the obesogenic role of PS in perturbing the gut-liver-adipose axis and altering nuclear receptor signaling and intermediary metabolism. Dietary interventions may limit the adverse metabolic effects of PS consumption.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-21T23:53:46.058Z","creation":"2025-04-05T19:17:51.306Z"},"accession":"S-EPMC10964747","cross_references":{"pubmed":["38291899"],"doi":["10.1093/toxsci/kfae013"]}}