{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["47(6)"],"submitter":["Hong SS"],"pubmed_abstract":["<i>Veratrum</i> spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (<b>1</b>), three stilbenoids (<b>2</b>-<b>4</b>), and five flavonoids (<b>5</b>-<b>9</b>), were isolated from the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from <i>V. versicolor</i> f. <i>viride</i> for the first time in the study. Among them, two flavone aglycone tricetins (<b>7</b> and <b>9</b>) have never been isolated from the genus <i>Veratrum</i> or the family Melanthiaceae. The ethanol extract and isolated compounds were assessed for their inhibitory effects on elastase, tyrosinase, and melanin synthesis. Compounds <b>5</b> and <b>7</b> inhibited elastase (IC<sub>50</sub>: 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively), whereas compounds <b>2</b>-<b>5</b> inhibited tyrosinase with IC<sub>50</sub> values in the range of 6.42 ~ 51.19 μM, respectively. In addition, compounds <b>3</b>-<b>6</b> and <b>8</b> exhibited dose-dependent inhibition (70.4% ~ 91.0%) of melanogenesis at a concentration of 100 μM."],"journal":["Turkish journal of chemistry"],"pagination":["1346-1354"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10965189"],"repository":["biostudies-literature"],"pubmed_title":["Phytochemical investigation on the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai and their biological activities."],"pmcid":["PMC10965189"],"pubmed_authors":["Choi CW","Jeong YW","Lee JE","Jeong W","Choi YH","Hong SS","Ahn EK","Oh JS","Lee JY","Ahn IH"],"additional_accession":[]},"is_claimable":false,"name":"Phytochemical investigation on the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai and their biological activities.","description":"<i>Veratrum</i> spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (<b>1</b>), three stilbenoids (<b>2</b>-<b>4</b>), and five flavonoids (<b>5</b>-<b>9</b>), were isolated from the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from <i>V. versicolor</i> f. <i>viride</i> for the first time in the study. Among them, two flavone aglycone tricetins (<b>7</b> and <b>9</b>) have never been isolated from the genus <i>Veratrum</i> or the family Melanthiaceae. The ethanol extract and isolated compounds were assessed for their inhibitory effects on elastase, tyrosinase, and melanin synthesis. Compounds <b>5</b> and <b>7</b> inhibited elastase (IC<sub>50</sub>: 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively), whereas compounds <b>2</b>-<b>5</b> inhibited tyrosinase with IC<sub>50</sub> values in the range of 6.42 ~ 51.19 μM, respectively. In addition, compounds <b>3</b>-<b>6</b> and <b>8</b> exhibited dose-dependent inhibition (70.4% ~ 91.0%) of melanogenesis at a concentration of 100 μM.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T23:53:49.461Z","creation":"2025-04-04T23:53:49.461Z"},"accession":"S-EPMC10965189","cross_references":{"pubmed":["38544705"],"doi":["10.55730/1300-0527.3618"]}}