biostudies-literatureUnknown47(6)Hong SS<i>Veratrum</i> spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (<b>1</b>), three stilbenoids (<b>2</b>-<b>4</b>), and five flavonoids (<b>5</b>-<b>9</b>), were isolated from the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from <i>V. versicolor</i> f. <i>viride</i> for the first time in the study. Among them, two flavone aglycone tricetins (<b>7</b> and <b>9</b>) have never been isolated from the genus <i>Veratrum</i> or the family Melanthiaceae. The ethanol extract and isolated compounds were assessed for their inhibitory effects on elastase, tyrosinase, and melanin synthesis. Compounds <b>5</b> and <b>7</b> inhibited elastase (IC₅₀: 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively), whereas compounds <b>2</b>-<b>5</b> inhibited tyrosinase with IC₅₀ values in the range of 6.42 ~ 51.19 μM, respectively. In addition, compounds <b>3</b>-<b>6</b> and <b>8</b> exhibited dose-dependent inhibition (70.4% ~ 91.0%) of melanogenesis at a concentration of 100 μM.Turkish journal of chemistry1346-1354https://www.ebi.ac.uk/biostudies/studies/S-EPMC10965189biostudies-literaturePhytochemical investigation on the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai and their biological activities.PMC10965189Choi CWJeong YWLee JEJeong WChoi YHHong SSAhn EKOh JSLee JYAhn IHfalsePhytochemical investigation on the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai and their biological activities.<i>Veratrum</i> spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (<b>1</b>), three stilbenoids (<b>2</b>-<b>4</b>), and five flavonoids (<b>5</b>-<b>9</b>), were isolated from the aerial parts of <i>Veratrum versicolor</i> f. <i>viride</i> Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from <i>V. versicolor</i> f. <i>viride</i> for the first time in the study. Among them, two flavone aglycone tricetins (<b>7</b> and <b>9</b>) have never been isolated from the genus <i>Veratrum</i> or the family Melanthiaceae. The ethanol extract and isolated compounds were assessed for their inhibitory effects on elastase, tyrosinase, and melanin synthesis. Compounds <b>5</b> and <b>7</b> inhibited elastase (IC₅₀: 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively), whereas compounds <b>2</b>-<b>5</b> inhibited tyrosinase with IC₅₀ values in the range of 6.42 ~ 51.19 μM, respectively. In addition, compounds <b>3</b>-<b>6</b> and <b>8</b> exhibited dose-dependent inhibition (70.4% ~ 91.0%) of melanogenesis at a concentration of 100 μM.2023-01-01T00:00:00Z20232025-04-04T23:53:49.461Z2025-04-04T23:53:49.461ZS-EPMC109651893854470510.55730/1300-0527.3618