{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeon W"],"funding":["Korean Government","National Research Foundation of Korea"],"pagination":["btae122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10965422"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(3)"],"pubmed_abstract":["<h4>Motivation</h4>Antibodies are proteins that the immune system produces in response to foreign pathogens. Designing antibodies that specifically bind to antigens is a key step in developing antibody therapeutics. The complementarity determining regions (CDRs) of the antibody are mainly responsible for binding to the target antigen, and therefore must be designed to recognize the antigen.<h4>Results</h4>We develop an antibody design model, AbFlex, that exhibits state-of-the-art performance in terms of structure prediction accuracy and amino acid recovery rate. Furthermore, >38% of newly designed antibody models are estimated to have better binding energies for their antigens than wild types. The effectiveness of the model is attributed to two different strategies that are developed to ov"],"journal":["Bioinformatics (Oxford, England)"],"pubmed_title":["AbFlex: designing antibody complementarity determining regions with flexible CDR definition."],"pmcid":["PMC10965422"],"funding_grant_id":["2019M3E5D6063871","2022R1A2C1006609","2021M3H9A2097443"],"pubmed_authors":["Kim D","Jeon W"],"additional_accession":[]},"is_claimable":false,"name":"AbFlex: designing antibody complementarity determining regions with flexible CDR definition.","description":"<h4>Motivation</h4>Antibodies are proteins that the immune system produces in response to foreign pathogens. Designing antibodies that specifically bind to antigens is a key step in developing antibody therapeutics. The complementarity determining regions (CDRs) of the antibody are mainly responsible for binding to the target antigen, and therefore must be designed to recognize the antigen.<h4>Results</h4>We develop an antibody design model, AbFlex, that exhibits state-of-the-art performance in terms of structure prediction accuracy and amino acid recovery rate. Furthermore, >38% of newly designed antibody models are estimated to have better binding energies for their antigens than wild types. The effectiveness of the model is attributed to two different strategies that are developed to ov","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-02T06:53:15.622Z","creation":"2025-04-04T23:01:34.487Z"},"accession":"S-EPMC10965422","cross_references":{"pubmed":["38449295"],"doi":["10.1093/bioinformatics/btae122"]}}