{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Davies D"],"funding":["Francis Crick Institute","Takeda Pharmaceutical Company","Medical Research Council","The Francis Crick Institute","Wellcome Trust"],"pagination":["420-432"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10965442"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(3)"],"pubmed_abstract":["Checkpoint inhibition (CPI), particularly that targeting the inhibitory coreceptor programmed cell death protein 1 (PD-1), has transformed oncology. Although CPI can derepress cancer (neo)antigen-specific αβ T cells that ordinarily show PD-1-dependent exhaustion, it can also be efficacious against cancers evading αβ T cell recognition. In such settings, γδ T cells have been implicated, but the functional relevance of PD-1 expression by these cells is unclear. Here we demonstrate that intratumoral TRDV1 transcripts (encoding the TCRδ chain of Vδ1<sup>+</sup> γδ T cells) predict anti-PD-1 CPI response in patients with melanoma, particularly those harboring below average neoantigens. Moreover, using a protocol yielding substantial numbers of tissue-derived Vδ1<sup>+</sup> cells, we show that "],"journal":["Nature cancer"],"pubmed_title":["PD-1 defines a distinct, functional, tissue-adapted state in Vδ1&lt;sup&gt;+&lt;/sup&gt; T cells with implications for cancer immunotherapy."],"pmcid":["PMC10965442"],"funding_grant_id":["FC001093","MR/K002627/1","CC2012","220589/Z/20/Z","CC1064"],"pubmed_authors":["Zlatareva I","Hayday A","Iannitto ML","Morton C","O'Neill O","Gillett C","Martin H","Munonyara M","Kamdar S","Biswas D","Nussbaumer O","Haque Y","Woolf R","Ndagire S","Davies D","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"PD-1 defines a distinct, functional, tissue-adapted state in Vδ1&lt;sup&gt;+&lt;/sup&gt; T cells with implications for cancer immunotherapy.","description":"Checkpoint inhibition (CPI), particularly that targeting the inhibitory coreceptor programmed cell death protein 1 (PD-1), has transformed oncology. Although CPI can derepress cancer (neo)antigen-specific αβ T cells that ordinarily show PD-1-dependent exhaustion, it can also be efficacious against cancers evading αβ T cell recognition. In such settings, γδ T cells have been implicated, but the functional relevance of PD-1 expression by these cells is unclear. Here we demonstrate that intratumoral TRDV1 transcripts (encoding the TCRδ chain of Vδ1<sup>+</sup> γδ T cells) predict anti-PD-1 CPI response in patients with melanoma, particularly those harboring below average neoantigens. Moreover, using a protocol yielding substantial numbers of tissue-derived Vδ1<sup>+</sup> cells, we show that ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T20:06:41.194Z","creation":"2025-04-04T22:59:46.837Z"},"accession":"S-EPMC10965442","cross_references":{"pubmed":["38172341"],"doi":["10.1038/s43018-023-00690-0"]}}