{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sharma A"],"funding":["Boehringer Ingelheim","Fonds de Recherche du Québec - Santé","Canadian Institutes of Health Research","CIHR"],"pagination":["737-747"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966270"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Aims
This study aimed to evaluate the bidirectional relationship between kidney and cardiovascular (CV) events in trial participants with type 2 diabetes and CV disease.Methods and results
Post hoc analyses of EMPA-REG OUTCOME using Cox regression models were performed to assess the association of baseline factors with risk of a kidney event and bidirectional associations of incident kidney events and CV events. Among placebo-treated participants, baseline factors significantly associated with greater kidney event risk included lower baseline estimated glomerular filtration rate, albuminuria, higher uric acid, low-density lipoprotein cholesterol levels, and prior heart failure (HF). Coronary artery disease was not associated with increased risk. In placebo-treated participa"],"journal":["ESC heart failure"],"pubmed_title":["Kidney and heart failure events are bidirectionally associated in patients with type 2 diabetes and cardiovascular disease."],"pmcid":["PMC10966270"],"funding_grant_id":["175095"],"pubmed_authors":["Verma S","Sharma A","Mattheus M","Fitchett D","Zannad F","Kraus BJ","Ofstad AP","Testani JM","Inzucchi SE","Wanner C"],"additional_accession":[]},"is_claimable":false,"name":"Kidney and heart failure events are bidirectionally associated in patients with type 2 diabetes and cardiovascular disease.","description":"Aims
This study aimed to evaluate the bidirectional relationship between kidney and cardiovascular (CV) events in trial participants with type 2 diabetes and CV disease.Methods and results
Post hoc analyses of EMPA-REG OUTCOME using Cox regression models were performed to assess the association of baseline factors with risk of a kidney event and bidirectional associations of incident kidney events and CV events. Among placebo-treated participants, baseline factors significantly associated with greater kidney event risk included lower baseline estimated glomerular filtration rate, albuminuria, higher uric acid, low-density lipoprotein cholesterol levels, and prior heart failure (HF). Coronary artery disease was not associated with increased risk. In placebo-treated participa","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-27T03:12:25.231Z","creation":"2025-04-06T18:45:38.009Z"},"accession":"S-EPMC10966270","cross_references":{"pubmed":["38155446"],"doi":["10.1002/ehf2.14601"]}}