{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(5)"],"submitter":["Zhang Y"],"funding":["NCATS","National Institute of Diabetes and Digestive and Kidney Diseases","NCI","NIGMS"],"pubmed_abstract":["<h4>Background & aims</h4>Restoring hepatic and peripheral insulin sensitivity is critical to prevent or reverse metabolic syndrome and type 2 diabetes. Glucose homeostasis comprises in part the complex regulation of hepatic glucose production and insulin-mediated glucose uptake and oxidation in peripheral tissues. We previously identified hepatocyte arginase 2 (Arg2) as an inducible ureahydrolase that improves glucose homeostasis and enhances glucose oxidation in multiple obese, insulin-resistant models. We therefore examined structure-function determinants through which hepatocyte Arg2 governs systemic insulin action and glucose oxidation.<h4>Methods</h4>To do this, we generated mice expressing wild-type murine Arg2, enzymatically inactive Arg2 (Arg2<sup>H160F</sup>) and Arg2 lacking its"],"journal":["Cellular and molecular gastroenterology and hepatology"],"pagination":["801-820"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966292"],"repository":["biostudies-literature"],"pubmed_title":["A Structure-function Analysis of Hepatocyte Arginase 2 Reveals Mitochondrial Ureahydrolysis as a Determinant of Glucose Oxidation."],"pmcid":["PMC10966292"],"pubmed_authors":["Wasserman HD","Higgins CB","Kelly SC","Adams JA","Zhang Y","DeBosch BJ","Sun J","Lantier L"],"additional_accession":[]},"is_claimable":false,"name":"A Structure-function Analysis of Hepatocyte Arginase 2 Reveals Mitochondrial Ureahydrolysis as a Determinant of Glucose Oxidation.","description":"<h4>Background & aims</h4>Restoring hepatic and peripheral insulin sensitivity is critical to prevent or reverse metabolic syndrome and type 2 diabetes. Glucose homeostasis comprises in part the complex regulation of hepatic glucose production and insulin-mediated glucose uptake and oxidation in peripheral tissues. We previously identified hepatocyte arginase 2 (Arg2) as an inducible ureahydrolase that improves glucose homeostasis and enhances glucose oxidation in multiple obese, insulin-resistant models. We therefore examined structure-function determinants through which hepatocyte Arg2 governs systemic insulin action and glucose oxidation.<h4>Methods</h4>To do this, we generated mice expressing wild-type murine Arg2, enzymatically inactive Arg2 (Arg2<sup>H160F</sup>) and Arg2 lacking its","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-21T21:26:07.134Z","creation":"2025-04-05T18:24:52.721Z"},"accession":"S-EPMC10966292","cross_references":{"pubmed":["38280549"],"doi":["10.1016/j.jcmgh.2024.01.016"]}}