{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Colombi I"],"funding":["Telethon Foundation","Telethon","European Research Council","Jérôme Lejeune Foundation"],"pagination":["109438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966311"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(4)"],"pubmed_abstract":["Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in adults. Depolarizing GABA responses have been well characterized at neuronal-population <i>average</i> level during typical neurodevelopment and partially in brain disorders. However, no investigation has specifically assessed whether a <i>mosaicism</i> of cells with either depolarizing or hyperpolarizing/inhibitory GABAergic responses exists in animals in health/disease at diverse developmental stages, including adulthood. Here, we showed that such mosaicism is present in wild-type (WT) and down syndrome (DS) neuronal networks, as assessed at increasing scales of complexity (cultures, brain slices, behaving mice). Nevertheless, WT mice presented a much lower percentage of cells with depolarizing GABA than DS mice. R"],"journal":["iScience"],"pubmed_title":["Heterogeneous subpopulations of GABA<sub>A</sub>R-responding neurons coexist across neuronal network scales and developmental stages in health and disease."],"pmcid":["PMC10966311"],"funding_grant_id":["TCP15021"],"pubmed_authors":["Cancedda L","Rastogi M","Chiappalone M","Colombi I","Chellali MM","Rosati S","Contestabile A","Parrini M","Alberti M","Nanni M","Potenzieri A"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneous subpopulations of GABA<sub>A</sub>R-responding neurons coexist across neuronal network scales and developmental stages in health and disease.","description":"Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in adults. Depolarizing GABA responses have been well characterized at neuronal-population <i>average</i> level during typical neurodevelopment and partially in brain disorders. However, no investigation has specifically assessed whether a <i>mosaicism</i> of cells with either depolarizing or hyperpolarizing/inhibitory GABAergic responses exists in animals in health/disease at diverse developmental stages, including adulthood. Here, we showed that such mosaicism is present in wild-type (WT) and down syndrome (DS) neuronal networks, as assessed at increasing scales of complexity (cultures, brain slices, behaving mice). Nevertheless, WT mice presented a much lower percentage of cells with depolarizing GABA than DS mice. R","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-07-16T00:19:10.874Z","creation":"2025-05-31T23:11:52.724Z"},"accession":"S-EPMC10966311","cross_references":{"pubmed":["38544574"],"doi":["10.1016/j.isci.2024.109438"]}}