{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barrera-Baena P"],"funding":["FRIAT","AMGEN Europe","Instituto de Salud Carlos III","Hospital Universitario Central de Asturias","Spanish Society of Nephrology","European Renal Association","Tecnología e Innovación","European Commission","Sociedad Asturiana Fomento Investigaciones Óseas"],"pagination":["618-626"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966329"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(4)"],"pubmed_abstract":["<h4>Background</h4>Bone fragility fractures are associated with high morbidity and mortality. This study analysed the association between the current biochemical parameters of chronic kidney disease-mineral and bone disorders (CKD-MBD) and bone fragility fractures in the COSMOS (Current management Of Secondary hyperparathyroidism: a Multicentre Observational Study) project.<h4>Methods</h4>COSMOS is a 3-year, multicentre, open cohort, prospective, observational study carried out in 6797 haemodialysis patients (227 centres from 20 European countries). The association of bone fragility fractures (outcome) with serum calcium, phosphate and parathyroid hormone (PTH) (exposure), was assessed using standard Cox proportional hazards regression and Cox proportional hazards regression for recurrent "],"journal":["Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association"],"pubmed_title":["Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients."],"pmcid":["PMC10966329"],"funding_grant_id":["GRUPIN14-028","ICI14/00107","PI20/00633","RD21/0005/0019","RD06/0016/1013","PI17/00384","RD12/0021/0023","IDI/2021/000080","IDI-2018-000152","RD21/0005/0001","RD16/0009/0017"],"pubmed_authors":["Rossi G","Steinbach J","Aucella F","Trudnowski S","Wambergue FP","Calvo MDP","Schurek HJ","Rodrigo Mateos PC","Pavukova","Stenger KO","Weiß M","Kavvadias D","Nefrologii O","Nazzaro L","Bidas K","Newstead C","Krzywicki P","Dell 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M","Valkovsky","Locatelli F","Rydzewski A","Dehnert","Malberti F","Scarlatella A","Krause R","Masson V","Martin-Carro B","Daschner M","Schaffer J","Sliwicka D","Alonso-Montes C","Bahlmann G","Ketteler M","Gallieni M","Ganzemuller C","Reyes GM","Van Bommel EFH","Metz-Kurschel U","Fulde R","Lorenz R","Sodemann","Preßler H","Mas EA","Brockmann C","Gross W","Wilkie M","Verseput GH","Verbeelen D","Majdalani G","Papantoniou A","Saveanu","Perez PS","Munatetto G","Will E","Hoekstra F","Coric-Martinovic V","Herrero GF","Robl B","Cuvelier R","Kamen W"],"additional_accession":[]},"is_claimable":false,"name":"Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients.","description":"<h4>Background</h4>Bone fragility fractures are associated with high morbidity and mortality. This study analysed the association between the current biochemical parameters of chronic kidney disease-mineral and bone disorders (CKD-MBD) and bone fragility fractures in the COSMOS (Current management Of Secondary hyperparathyroidism: a Multicentre Observational Study) project.<h4>Methods</h4>COSMOS is a 3-year, multicentre, open cohort, prospective, observational study carried out in 6797 haemodialysis patients (227 centres from 20 European countries). The association of bone fragility fractures (outcome) with serum calcium, phosphate and parathyroid hormone (PTH) (exposure), was assessed using standard Cox proportional hazards regression and Cox proportional hazards regression for recurrent ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-09T11:52:19.205Z","creation":"2025-04-06T18:45:44.376Z"},"accession":"S-EPMC10966329","cross_references":{"pubmed":["37660283"],"doi":["10.1093/ndt/gfad190"]}}