{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lei M"],"funding":["U.S. National Science Foundation","The Shanghai Sailing Program","111 Project","The Shanghai Postdoctoral Excellence Program","the Betty and Gordon Moore Foundation","National Natural Science Foundation of China","China Postdoctoral Science Foundation","National Postdoctoral Program for Innovative Talents","Higher Education Discipline Innovation Project","National Key Research and Development Program of China","National Science Foundation","Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee"],"pagination":["e2307606"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966538"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(12)"],"pubmed_abstract":["Biology remains the envy of flexible soft matter fabrication because it can satisfy multiple functional needs by organizing a small set of proteins and polysaccharides into hierarchical systems with controlled heterogeneity in composition and microstructure. Here, it is reported that controlled, mild electronic inputs (<10 V; <20 min) induce a homogeneous gelatin-chitosan mixture to undergo sorting and bottom-up self-assembly into a Janus film with compositional gradient (i.e., from chitosan-enriched layer to chitosan/gelatin-contained layer) and tunable dense-porous gradient microstructures (e.g., porosity, pore size, and ratio of dense to porous layers). This Janus film performs is shown multiple functions for guided bone regeneration: the integration of compositional and microstructural"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Electro-Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration."],"pmcid":["PMC10966538"],"funding_grant_id":["BX20230122","11395","23YF1409700","32301113","32171341","2022157","21XD1421100","CBET‐1932963","2021YFB3800800","CBET-1932963","2022M721136","B14018","21S31901500","31922041"],"pubmed_authors":["Payne GF","Lei M","Zhu J","Liao H","Wang S","Qu X","Wan H","Liu C","Zhou H"],"additional_accession":[]},"is_claimable":false,"name":"Electro-Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration.","description":"Biology remains the envy of flexible soft matter fabrication because it can satisfy multiple functional needs by organizing a small set of proteins and polysaccharides into hierarchical systems with controlled heterogeneity in composition and microstructure. Here, it is reported that controlled, mild electronic inputs (<10 V; <20 min) induce a homogeneous gelatin-chitosan mixture to undergo sorting and bottom-up self-assembly into a Janus film with compositional gradient (i.e., from chitosan-enriched layer to chitosan/gelatin-contained layer) and tunable dense-porous gradient microstructures (e.g., porosity, pore size, and ratio of dense to porous layers). This Janus film performs is shown multiple functions for guided bone regeneration: the integration of compositional and microstructural","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-27T03:09:47.171Z","creation":"2025-04-27T03:09:47.171Z"},"accession":"S-EPMC10966538","cross_references":{"pubmed":["38225697"],"doi":["10.1002/advs.202307606"]}}