{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feng B"],"funding":["Shanghai Municipal Science and Technology Major Project","Interdisciplinary Program of Shanghai Jiao Tong University","Shanghai Committee of Science and Technology, China","Cross disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai JiaoTong university School of Medicine","Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases","Natural Science Foundation of Shanghai","Natural Science Foundation of Shanghai Municipality","National Natural Science Foundation of China"],"pagination":["e2305682"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966548"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(12)"],"pubmed_abstract":["There are no Food and Drug Administration-approved drugs for treating noise-induced hearing loss (NIHL), reflecting the absence of clear specific therapeutic targets and effective delivery strategies. Noise trauma is demonstrated results in nicotinamide adenine dinucleotide (NAD+) downregulation and mitochondrial dysfunction in cochlear hair cells (HCs) and spiral ganglion neurons (SGNs) in mice, and NAD+ boosted by nicotinamide (NAM) supplementation maintains cochlear mitochondrial homeostasis and prevents neuroexcitatory toxic injury in vitro and ex vivo, also significantly ameliorated NIHL in vivo. To tackle the limited drug delivery efficiency due to sophisticated anatomical barriers and unique clearance pathway in ear, personalized NAM-encapsulated porous gelatin methacryloyl (PGMA@NAM) are developed based on anatomy topography of murine temporal bone by micro-computed tomography and reconstruction of round window (RW) niche, realizing hydrogel in situ implantation completely, NAM sustained-release and long-term auditory preservation in mice. This study strongly supports personalized PGMA@NAM as NIHL protection drug with effective inner ear delivery, providing new inspiration for drug-based treatment of NIHL."],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Personalized Porous Gelatin Methacryloyl Sustained-Release Nicotinamide Protects Against Noise-Induced Hearing Loss."],"pmcid":["PMC10966548"],"funding_grant_id":["82371144","82371145","14DZ2260300","JYJC202104","21ZR1437600","81730028","21JC1404000","81970872","JYJC202231","82122019","82201275","2018SHZDZX05","YG2022QN064"],"pubmed_authors":["Zhang W","Dong T","Liu Y","Zheng X","Jin C","Tao Y","Wang X","Feng B","Song X","Cheng Z","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Personalized Porous Gelatin Methacryloyl Sustained-Release Nicotinamide Protects Against Noise-Induced Hearing Loss.","description":"There are no Food and Drug Administration-approved drugs for treating noise-induced hearing loss (NIHL), reflecting the absence of clear specific therapeutic targets and effective delivery strategies. Noise trauma is demonstrated results in nicotinamide adenine dinucleotide (NAD+) downregulation and mitochondrial dysfunction in cochlear hair cells (HCs) and spiral ganglion neurons (SGNs) in mice, and NAD+ boosted by nicotinamide (NAM) supplementation maintains cochlear mitochondrial homeostasis and prevents neuroexcitatory toxic injury in vitro and ex vivo, also significantly ameliorated NIHL in vivo. To tackle the limited drug delivery efficiency due to sophisticated anatomical barriers and unique clearance pathway in ear, personalized NAM-encapsulated porous gelatin methacryloyl (PGMA@NAM) are developed based on anatomy topography of murine temporal bone by micro-computed tomography and reconstruction of round window (RW) niche, realizing hydrogel in situ implantation completely, NAM sustained-release and long-term auditory preservation in mice. This study strongly supports personalized PGMA@NAM as NIHL protection drug with effective inner ear delivery, providing new inspiration for drug-based treatment of NIHL.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-27T03:16:46.123Z","creation":"2025-04-06T18:46:23.912Z"},"accession":"S-EPMC10966548","cross_references":{"pubmed":["38225752"],"doi":["10.1002/advs.202305682"]}}