{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kong M"],"funding":["NSFC","National Natural Science Foundation of China","Henan Key Laboratory of Organic Functional Molecules and Drug Innovation"],"pagination":["e2307773"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966550"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(12)"],"pubmed_abstract":["An unprecedented enantioselective protonation reaction enabled by photoredox catalytic radical coupling is developed. Under cooperative dicynopyrazine-derived chromophore (DPZ) as a photosensitizer and a chiral phosphoric acid catalyst, and Hantzsch ester as a sacrificial reductant, the transformations between α-substituted enones and cyanoazaarenes or 2-(chloromethyl)azaaren-1-iums can proceed a tandem reduction, radical coupling, and enantioselective protonation process efficiently. Two classes of pharmaceutically important enantioenriched azaarene variants, which contain a synthetically versatile ketone-substituted tertiary carbon stereocenter at the β- or γ-position of the azaarenes, are synthesized with high yields and ees."],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Radical Cross Coupling and Enantioselective Protonation through Asymmetric Photoredox Catalysis."],"pmcid":["PMC10966550"],"funding_grant_id":["22171072","21925103"],"pubmed_authors":["Yin Y","Kong M","Jiang Z","Zhang J","Ban X","Wang Z","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Radical Cross Coupling and Enantioselective Protonation through Asymmetric Photoredox Catalysis.","description":"An unprecedented enantioselective protonation reaction enabled by photoredox catalytic radical coupling is developed. Under cooperative dicynopyrazine-derived chromophore (DPZ) as a photosensitizer and a chiral phosphoric acid catalyst, and Hantzsch ester as a sacrificial reductant, the transformations between α-substituted enones and cyanoazaarenes or 2-(chloromethyl)azaaren-1-iums can proceed a tandem reduction, radical coupling, and enantioselective protonation process efficiently. Two classes of pharmaceutically important enantioenriched azaarene variants, which contain a synthetically versatile ketone-substituted tertiary carbon stereocenter at the β- or γ-position of the azaarenes, are synthesized with high yields and ees.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-25T21:41:49.821Z","creation":"2025-04-06T08:48:46.696Z"},"accession":"S-EPMC10966550","cross_references":{"pubmed":["38233152"],"doi":["10.1002/advs.202307773"]}}