{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun L"],"funding":["Shanghai Municipal Health Commission","National Natural Science Foundation of China","Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure","Shanghai Sailing Program"],"pagination":["e2307278"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966556"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(12)"],"pubmed_abstract":["Activating cGAS-STING pathway has great potential to achieve effective antitumor immunotherapy. However, mutant p53 (mutp53), a commonly observed genetic alteration in over 50% of human cancer, will impede the therapeutic performance of the cGAS-STING pathway. Herein, multifunctional ZIF-8@MnO<sub>2</sub> nanoparticles are constructed to degrade mutp53 and facilitate the cGAS-STING pathway. The synthesized ZIF-8@MnO<sub>2</sub> can release Zn<sup>2+</sup> and Mn<sup>2+</sup> in cancer cells to induce oxidative stress and cytoplasmic leakage of fragmented mitochondrial double-stranded DNAs (dsDNAs). Importantly, the released Zn<sup>2+</sup> induces variable degradation of multifarious p53 mutants through proteasome ubiquitination, which can alleviate the inhibitory effects of mutp53 on the "],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Nanoscale Metal-Organic Frameworks-Mediated Degradation of Mutant p53 Proteins and Activation of cGAS-STING Pathway for Enhanced Cancer Immunotherapy."],"pmcid":["PMC10966556"],"funding_grant_id":["82372098","21YF1411500","SKL202212SIC","82102190","2022JC006"],"pubmed_authors":["Sun L","Zheng X","Ji X","Qin X","Ni D","Gao H","Wang H","Jiao Y","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Nanoscale Metal-Organic Frameworks-Mediated Degradation of Mutant p53 Proteins and Activation of cGAS-STING Pathway for Enhanced Cancer Immunotherapy.","description":"Activating cGAS-STING pathway has great potential to achieve effective antitumor immunotherapy. However, mutant p53 (mutp53), a commonly observed genetic alteration in over 50% of human cancer, will impede the therapeutic performance of the cGAS-STING pathway. Herein, multifunctional ZIF-8@MnO<sub>2</sub> nanoparticles are constructed to degrade mutp53 and facilitate the cGAS-STING pathway. The synthesized ZIF-8@MnO<sub>2</sub> can release Zn<sup>2+</sup> and Mn<sup>2+</sup> in cancer cells to induce oxidative stress and cytoplasmic leakage of fragmented mitochondrial double-stranded DNAs (dsDNAs). Importantly, the released Zn<sup>2+</sup> induces variable degradation of multifarious p53 mutants through proteasome ubiquitination, which can alleviate the inhibitory effects of mutp53 on the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T12:24:46.297Z","creation":"2025-04-04T12:24:46.297Z"},"accession":"S-EPMC10966556","cross_references":{"pubmed":["38225693"],"doi":["10.1002/advs.202307278"]}}