{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ballaben AS"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","NIAID NIH HHS","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Fundação de Amparo à Pesquisa do Estado de São Paulo","National Institutes of Health"],"pagination":["104658"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966726"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["87"],"pubmed_abstract":["IMP-1-producing Pseudomonas aeruginosa was first reported in Japan and since then, bacteria with this metallo-β-lactamase have been detected worldwide. Pseudomonas monteilii (part of P. putida group) were considered an environmental pathogen with low virulence potential; however, multidrug-resistant and carbapenem-resistant P. monteilii have emerged. The present study reports the draft sequence of an extensively drug-resistant IMP-16-producing P. monteilii 597/14 isolated from cerebrospinal fluid in 2014. The sequencing data revealed bla<sub>IMP-16</sub> as a gene cassette on class 1 integron, In1738 characterized in this study. Furthermore, the resistome of Pm597/14 consisted of 7 resistance genes (aadA1b, strA, strB, aacA4, bla<sub>IMP-16</sub>, bla<sub>OXA-2</sub>, sul1) and diverse virulence determinants involved in the adherence, LPS, antiphagocytosis, iron uptake and mercuric resistance. Although different virulence determinants were found in this study, using Galleria mellonella infection model, Pm597/14 did not kill any larvae between 7 days post-infection. P. monteilii isolates have been reported from clinical and environmental sources, carrying different MBL genes showing its potential role as their reservoir."],"journal":["Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"],"pubmed_title":["Extensively drug-resistant IMP-16-producing Pseudomonas monteilii isolated from cerebrospinal fluid."],"pmcid":["PMC10966726"],"funding_grant_id":["R21AI135522","2015/23484–9","R01 AI104895","R01AI104895","2015/11728–0","2014/14494–8","R21 AI135522"],"pubmed_authors":["Ferreira JC","Andrade LN","de Oliveira Garcia D","Doi Y","Darini ALC","Galetti R","Ballaben AS"],"additional_accession":[]},"is_claimable":false,"name":"Extensively drug-resistant IMP-16-producing Pseudomonas monteilii isolated from cerebrospinal fluid.","description":"IMP-1-producing Pseudomonas aeruginosa was first reported in Japan and since then, bacteria with this metallo-β-lactamase have been detected worldwide. Pseudomonas monteilii (part of P. putida group) were considered an environmental pathogen with low virulence potential; however, multidrug-resistant and carbapenem-resistant P. monteilii have emerged. The present study reports the draft sequence of an extensively drug-resistant IMP-16-producing P. monteilii 597/14 isolated from cerebrospinal fluid in 2014. The sequencing data revealed bla<sub>IMP-16</sub> as a gene cassette on class 1 integron, In1738 characterized in this study. Furthermore, the resistome of Pm597/14 consisted of 7 resistance genes (aadA1b, strA, strB, aacA4, bla<sub>IMP-16</sub>, bla<sub>OXA-2</sub>, sul1) and diverse virulence determinants involved in the adherence, LPS, antiphagocytosis, iron uptake and mercuric resistance. Although different virulence determinants were found in this study, using Galleria mellonella infection model, Pm597/14 did not kill any larvae between 7 days post-infection. P. monteilii isolates have been reported from clinical and environmental sources, carrying different MBL genes showing its potential role as their reservoir.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-21T21:30:24.497Z","creation":"2025-04-05T18:22:17.345Z"},"accession":"S-EPMC10966726","cross_references":{"pubmed":["33271337"],"doi":["10.1016/j.meegid.2020.104658"]}}