{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Radtke AJ"],"funding":["National Institute of Allergy and Infectious Diseases","Intramural NIH HHS","Frederick National Laboratory for Cancer Research","European Research Council","National Cancer Institute","NCI NIH HHS","AstraZeneca","National Institutes of Health"],"pagination":["444-463.e10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966827"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(3)"],"pubmed_abstract":["Follicular lymphoma (FL) is a generally incurable malignancy that evolves from developmentally blocked germinal center (GC) B cells. To promote survival and immune escape, tumor B cells undergo significant genetic changes and extensively remodel the lymphoid microenvironment. Dynamic interactions between tumor B cells and the tumor microenvironment (TME) are hypothesized to contribute to the broad spectrum of clinical behaviors observed among FL patients. Despite the urgent need, existing clinical tools do not reliably predict disease behavior. Using a multi-modal strategy, we examined cell-intrinsic and -extrinsic factors governing progression and therapeutic outcomes in FL patients enrolled onto a prospective clinical trial. By leveraging the strengths of each platform, we identify sever"],"journal":["Cancer cell"],"pubmed_title":["Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients."],"pmcid":["PMC10966827"],"funding_grant_id":["75N91019D00024","Z01 SC004024","771883","HHSN316201300006W / 75N93022F00001","Z01 AI000545","ZIA BC011914","Z01 BC011006"],"pubmed_authors":["Radtke AJ","Fowler N","Ataullakhanov R","Hernandez JM","Speranza E","Lozinsky Y","Jaffe ES","Shaffer AL","Sorokina M","Svekolkin V","Isaev S","Wilson WH","Galkin I","Huang DW","Bagaev A","Davies-Hill T","Varlamova A","Perelman G","Kelly M","Muppidi J","Lowekamp BC","Yao L","Postovalova E","Germain RN","Ovcharov P","Meerson M","Sarachakov A","Phelan JD","Sharun A","Nuzhdina E","Staudt LM","Polyakova M","Wiebe D","Nomie K","Kudryashova O","Pittaluga S","Kotlov N","Davis JL","Yaniv Z","Roschewski M","Jonigk D"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients.","description":"Follicular lymphoma (FL) is a generally incurable malignancy that evolves from developmentally blocked germinal center (GC) B cells. To promote survival and immune escape, tumor B cells undergo significant genetic changes and extensively remodel the lymphoid microenvironment. Dynamic interactions between tumor B cells and the tumor microenvironment (TME) are hypothesized to contribute to the broad spectrum of clinical behaviors observed among FL patients. Despite the urgent need, existing clinical tools do not reliably predict disease behavior. Using a multi-modal strategy, we examined cell-intrinsic and -extrinsic factors governing progression and therapeutic outcomes in FL patients enrolled onto a prospective clinical trial. By leveraging the strengths of each platform, we identify sever","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-02T00:01:23.722Z","creation":"2025-04-04T20:25:34.294Z"},"accession":"S-EPMC10966827","cross_references":{"pubmed":["38428410"],"doi":["10.1016/j.ccell.2024.02.001"]}}