{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Olczak T"],"funding":["Narodowe Centrum Nauki","Narodowe Centrum Nauki (NCN)","Biotechnology and Biological Sciences Research Council"],"pagination":["e0013123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966948"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(1)"],"pubmed_abstract":["<h4>Summary</h4>Heme (iron protoporphyrin IX, FePPIX) is the main source of iron and PPIX for host-associated pathogenic bacteria, including members of the Bacteroidota (formerly Bacteroidetes) phylum. <i>Porphyromonas gingivalis</i>, a keystone oral pathogen, uses a unique heme uptake (Hmu) system, comprising a hemophore-like protein, designated as the first member of the novel HmuY family. Compared to classical, secreted hemophores utilized by Gram-negative bacteria or near-iron transporter domain-based hemophores utilized by Gram-positive bacteria, the HmuY family comprises structurally similar proteins that have undergone diversification during evolution. The best characterized are <i>P. gingivalis</i> HmuY and its homologs from <i>Tannerella forsythia</i> (Tfo), <i>Prevotella intermed"],"journal":["Microbiology and molecular biology reviews : MMBR"],"pubmed_title":["Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution."],"pmcid":["PMC10966948"],"funding_grant_id":["2015/17/B/NZ6/01969","2019/33/B/NZ6/00292","2021/41/B/NZ6/00702","2016/23/B/NZ6/00080","BB/R000220/1","2014/15/B/NZ6/01723"],"pubmed_authors":["Olczak T","Antonyuk SV","Smalley JW","Smiga M"],"additional_accession":[]},"is_claimable":false,"name":"Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution.","description":"<h4>Summary</h4>Heme (iron protoporphyrin IX, FePPIX) is the main source of iron and PPIX for host-associated pathogenic bacteria, including members of the Bacteroidota (formerly Bacteroidetes) phylum. <i>Porphyromonas gingivalis</i>, a keystone oral pathogen, uses a unique heme uptake (Hmu) system, comprising a hemophore-like protein, designated as the first member of the novel HmuY family. Compared to classical, secreted hemophores utilized by Gram-negative bacteria or near-iron transporter domain-based hemophores utilized by Gram-positive bacteria, the HmuY family comprises structurally similar proteins that have undergone diversification during evolution. The best characterized are <i>P. gingivalis</i> HmuY and its homologs from <i>Tannerella forsythia</i> (Tfo), <i>Prevotella intermed","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-21T21:30:08.134Z","creation":"2025-04-05T18:21:18.18Z"},"accession":"S-EPMC10966948","cross_references":{"pubmed":["38305743"],"doi":["10.1128/mmbr.00131-23"]}}