biostudies-literatureRuzzenente ANCI NIH HHS1098-1110https://www.ebi.ac.uk/biostudies/studies/S-EPMC10966966biostudies-literatureUnknown30(9)<h4>Background</h4>The aim of this multicentric study was to investigate the impact of tumor location and size on the difficulty of Laparoscopic-Left Hepatectomy (L-LH).<h4>Methods</h4>Patients who underwent L-LH performed across 46 centers from 2004 to 2020 were analyzed. Of 1236 L-LH, 770 patients met the study criteria. Baseline clinical and surgical characteristics with a potential impact on LLR were included in a multi-label conditional interference tree. Tumor size cut-off was algorithmically determined.<h4>Results</h4>Patients were stratified into 3 groups based on tumor location and dimension: 457 in antero-lateral location (Group 1), 144 in postero-superior segment (4a) with tumor size ≤40 mm (Group 2), and 169 in postero-superior segment (4a) with tumor size >40 mm (Group 3). PatJournal of hepato-biliary-pancreatic sciencesSub-classification of laparoscopic left hepatectomy based on hierarchic interaction of tumor location and size with perioperative outcomes.PMC10966966P30 CA008748Yong CCMocchegianni FKingham TPLai ECHNghia PPFondevila CAbu Hilal MArdito FWang HPLopez-Ben SRuzzenente ALong TCDMazzaferro VVani SGiustizieri UDi Benedetto FEfanov MColasanti MIvanecz AD'Hondt MAldrighetti LYu SKabir TKrenzien FCipriani FSyn NLJang JYLee BFretland AALee LSWakabayashi GInternational robotic and laparoscopic liver resection study group investigators are co-authors of this studyLee KFPoletto EFerrero ASucandy IGoh BKPEttorre GMLopez-Lopez VCheung TTPrieto MGiglio MTroisi RISalimgereeva DSchotte HArmstrong TChiow AKHD'Silva MGiuliante FMonden KMagistri PSaleh MSoubrane OMarino MVChoi GHTang CNCitterio DChen ZWang XLee JHMontalti RGhotbi JKadam PValle BDKruger JAPMazzotta APascual FKojima MAlikhanov RSugioka AChen KHCoelho FFSchmelzle MRobert MCIGastaca MChong CCCherqui DLiu QLiu RPratschke JVivarelli MSiow TFHerman PLevi Sandri GBRotellar FKato YSutcliffe RPMishima KAghayan DLDe Meyere CFuks DEdwin BHan HSChoi SHLim CScatton ORobles-Campos RYin MfalseSub-classification of laparoscopic left hepatectomy based on hierarchic interaction of tumor location and size with perioperative outcomes.<h4>Background</h4>The aim of this multicentric study was to investigate the impact of tumor location and size on the difficulty of Laparoscopic-Left Hepatectomy (L-LH).<h4>Methods</h4>Patients who underwent L-LH performed across 46 centers from 2004 to 2020 were analyzed. Of 1236 L-LH, 770 patients met the study criteria. Baseline clinical and surgical characteristics with a potential impact on LLR were included in a multi-label conditional interference tree. Tumor size cut-off was algorithmically determined.<h4>Results</h4>Patients were stratified into 3 groups based on tumor location and dimension: 457 in antero-lateral location (Group 1), 144 in postero-superior segment (4a) with tumor size ≤40 mm (Group 2), and 169 in postero-superior segment (4a) with tumor size >40 mm (Group 3). Pat2023-01-01T00:00:00Z2023 Sep2025-04-21T22:10:47.303Z2025-04-05T18:34:54.854ZS-EPMC109669663687209810.1002/jhbp.1323