{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(13)"],"submitter":["Manna S"],"pubmed_abstract":["The discovery of a new class of heteroatom-rich boron-containing molecules (BCMs) and iterative cross-coupling (ICC) partners created a toolbox for future drug developments using organoboron compounds. Herein, we report the potential utility of 1,3-enyne MIDA boronates to access diverse <i>gem</i>-difluoro MIDA boronates <i>via</i> novel 1,2-alkyne shift. This unique reactivity of 1,3-enyne MIDA boronates offers facile access to previously challenging β-difluorinated alkyl borons. Furthermore, we demonstrated the synthesis of various novel furan-based BCMs <i>via</i> 5-<i>endo-dig</i> cyclization and iterative coupling partners <i>via</i> copper-catalyzed hydroboration and platinum-catalyzed diboration reaction."],"journal":["Chemical science"],"pagination":["4989-4995"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10967263"],"repository":["biostudies-literature"],"pubmed_title":["Reactivity of 1,3-enyne MIDA boronates: exploration of novel 1,2-alkyne shift <i>via gem</i>-difluorination."],"pmcid":["PMC10967263"],"pubmed_authors":["Aich D","Hazra S","Khandelwal S","Manna S","Panda S"],"additional_accession":[]},"is_claimable":false,"name":"Reactivity of 1,3-enyne MIDA boronates: exploration of novel 1,2-alkyne shift <i>via gem</i>-difluorination.","description":"The discovery of a new class of heteroatom-rich boron-containing molecules (BCMs) and iterative cross-coupling (ICC) partners created a toolbox for future drug developments using organoboron compounds. Herein, we report the potential utility of 1,3-enyne MIDA boronates to access diverse <i>gem</i>-difluoro MIDA boronates <i>via</i> novel 1,2-alkyne shift. This unique reactivity of 1,3-enyne MIDA boronates offers facile access to previously challenging β-difluorinated alkyl borons. Furthermore, we demonstrated the synthesis of various novel furan-based BCMs <i>via</i> 5-<i>endo-dig</i> cyclization and iterative coupling partners <i>via</i> copper-catalyzed hydroboration and platinum-catalyzed diboration reaction.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T23:53:18.26Z","creation":"2025-04-04T23:53:18.26Z"},"accession":"S-EPMC10967263","cross_references":{"pubmed":["38550673"],"doi":["10.1039/d3sc06918d"]}}