{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu Y"],"funding":["Jiangsu Shuang Chuang Ren Cai program","Jiangsu Shuang Chuang Tuan Dui program","National Natural Science Foundation of China","Key International Cooperation Program of the National Natural Science Foundation of China"],"pagination":["979"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10967341"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(6)"],"pubmed_abstract":["A prior investigation revealed that a lack of Zinc (Zn) could hinder intestinal cell proliferation in broiler chickens; however, the mechanisms responsible for this effect remain unclear. We aimed to investigate the possible mechanisms of dietary Zn deficiency in inhibiting the jejunal cell proliferation of broilers. For this study, a total of 112 chickens (21 days old) were randomly divided into two treatments (seven replicate cages per treatment, eight chickens per replicate cage): the control group (CON) and the Zn deficiency group. The duration of feeding was 21 d. Chickens in the control group were provided with a basal diet containing an extra addition of 40 mg Zn/kg in the form of Zn sulfate, whereas chickens in the Zn deficiency group were given the basal diet with no Zn supplement"],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["Dietary Zn Deficiency Inhibits Cell Proliferation via the GPR39-Mediated Suppression of the PI3K/AKT/mTOR Signaling Pathway in the Jejunum of Broilers."],"pmcid":["PMC10967341"],"funding_grant_id":["JSSCRC2021541","JSSCTD202147","31972583","32120103011"],"pubmed_authors":["Zhang W","Hu Y","Yang K","Li T","Wang S","Cui X","Xue M","Zhang L","Luo X"],"additional_accession":[]},"is_claimable":false,"name":"Dietary Zn Deficiency Inhibits Cell Proliferation via the GPR39-Mediated Suppression of the PI3K/AKT/mTOR Signaling Pathway in the Jejunum of Broilers.","description":"A prior investigation revealed that a lack of Zinc (Zn) could hinder intestinal cell proliferation in broiler chickens; however, the mechanisms responsible for this effect remain unclear. We aimed to investigate the possible mechanisms of dietary Zn deficiency in inhibiting the jejunal cell proliferation of broilers. For this study, a total of 112 chickens (21 days old) were randomly divided into two treatments (seven replicate cages per treatment, eight chickens per replicate cage): the control group (CON) and the Zn deficiency group. The duration of feeding was 21 d. Chickens in the control group were provided with a basal diet containing an extra addition of 40 mg Zn/kg in the form of Zn sulfate, whereas chickens in the Zn deficiency group were given the basal diet with no Zn supplement","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-21T21:33:54.746Z","creation":"2025-04-05T18:23:03.397Z"},"accession":"S-EPMC10967341","cross_references":{"pubmed":["38540076"],"doi":["10.3390/ani14060979"]}}