{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cervantes M"],"funding":["DELTAVIT-GROUPE CCPA","DELTAVIT CCPA Group"],"pagination":["973"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10967614"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(6)"],"pubmed_abstract":["Exposure to heat stress (HS) detrimentally affects pig performance. This study explored whether a dietary phytogenic solution based on <i>Capsicum</i> spp. (PHY) could enhance the thermal tolerance of heat-stressed growing pigs. Forty-two individually housed pigs were randomly assigned to three treatments: thermoneutral pigs on a control diet (TN-C) and pigs subjected to HS fed the control diet either without (HS-C) or with supplemental PHY (HS-PHY). The TN-C group exhibited increased average daily gain (ADG) and feed intake (FI) compared to both HS-C (<i>p</i> < 0.01) and HS-PHY pigs (<i>p</i> < 0.05) and better feed efficiency compared to HS-C pigs only (<i>p</i> < 0.01). However, the HS-PHY pigs showed significantly higher FI (<i>p</i> < 0.01) and ADG (<i>p</i> < 0.05) compared to HS-C pigs. HS pigs displayed higher body temperatures (BTs) than TN pigs (<i>p</i> < 0.01), yet HS-PHY pigs experienced a lesser increase in BT compared to HS-C pigs (<i>p</i> < 0.05). Supplementation with PHY mitigated some effects of HS, increasing serum superoxide dismutase and catalase activity, reducing HSP90 expression in <i>longissimus dorsi</i> muscle, and elevating jejunal villus height compared to HS-C pigs (<i>p</i> < 0.05), reaching levels akin to TN-C pigs. Additionally, PHY supplementation resulted in lower serum urea levels than HS-C pigs (<i>p</i> < 0.01) and similar myosin gene expression to TN-C pigs (<i>p</i> > 0.1), suggesting enhanced amino acid post-absorptive utilization for lean tissue growth. In conclusion, dietary PHY supplementation partially offset the adverse effects of HS on pig performance by improving thermal tolerance."],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["A Capsaicin-Based Phytogenic Solution Improves Performance and Thermal Tolerance of Heat-Stressed Growing Pigs."],"pmcid":["PMC10967614"],"funding_grant_id":["Effect of the plant feed additive containing extracts of Capsicum spp. Pipper nigrum and Zingiber officinales on intestinal function and integrity of pigs exposed to heat stress conditions","CER-2022-1"],"pubmed_authors":["Cervantes M","Soto M","Gomez AJ","Sakkas P","Quilichini N","Camacho RL","Arce N","Morales A"],"additional_accession":[]},"is_claimable":false,"name":"A Capsaicin-Based Phytogenic Solution Improves Performance and Thermal Tolerance of Heat-Stressed Growing Pigs.","description":"Exposure to heat stress (HS) detrimentally affects pig performance. This study explored whether a dietary phytogenic solution based on <i>Capsicum</i> spp. (PHY) could enhance the thermal tolerance of heat-stressed growing pigs. Forty-two individually housed pigs were randomly assigned to three treatments: thermoneutral pigs on a control diet (TN-C) and pigs subjected to HS fed the control diet either without (HS-C) or with supplemental PHY (HS-PHY). The TN-C group exhibited increased average daily gain (ADG) and feed intake (FI) compared to both HS-C (<i>p</i> < 0.01) and HS-PHY pigs (<i>p</i> < 0.05) and better feed efficiency compared to HS-C pigs only (<i>p</i> < 0.01). However, the HS-PHY pigs showed significantly higher FI (<i>p</i> < 0.01) and ADG (<i>p</i> < 0.05) compared to HS-C pigs. HS pigs displayed higher body temperatures (BTs) than TN pigs (<i>p</i> < 0.01), yet HS-PHY pigs experienced a lesser increase in BT compared to HS-C pigs (<i>p</i> < 0.05). Supplementation with PHY mitigated some effects of HS, increasing serum superoxide dismutase and catalase activity, reducing HSP90 expression in <i>longissimus dorsi</i> muscle, and elevating jejunal villus height compared to HS-C pigs (<i>p</i> < 0.05), reaching levels akin to TN-C pigs. Additionally, PHY supplementation resulted in lower serum urea levels than HS-C pigs (<i>p</i> < 0.01) and similar myosin gene expression to TN-C pigs (<i>p</i> > 0.1), suggesting enhanced amino acid post-absorptive utilization for lean tissue growth. In conclusion, dietary PHY supplementation partially offset the adverse effects of HS on pig performance by improving thermal tolerance.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-21T21:29:07.931Z","creation":"2025-04-05T18:22:48.963Z"},"accession":"S-EPMC10967614","cross_references":{"pubmed":["38540070"],"doi":["10.3390/ani14060973"]}}