{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(15)"],"submitter":["Buchele WRE"],"pubmed_abstract":["Synthesis and characterization of the first two cyclic ethylene-bridged tetradentate NHC ligands, with an unsaturated (imidazole) and saturated backbone (2-imidazoline), are described. Complexes of both ligands containing palladium(ii) have been obtained. For platinum(ii) and gold(iii), only the unsaturated tetracarbene complexes could be isolated. The attempts to synthesize a methylene-bridged 2-imidazoline macrocycle are also described. Furthermore, a novel bisimidazolinium ligand precursor and its open-chain Pd<sup>II</sup> and Pt<sup>II</sup> tetracarbene complexes are obtained. Finally, it is shown that the unsaturated gold(iii) tetracarbene is able to induce apoptosis in malignant SK-N-AS neuroblastoma cells <i>via</i> the mitochondrial and ROS pathway and overcomes resistance to cisplatin <i>in vitro</i>."],"journal":["RSC advances"],"pagination":["10244-10254"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10967698"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis, characterization, and biomedical evaluation of ethylene-bridged tetra-NHC Pd(ii), Pt(ii) and Au(iii) complexes, with apoptosis-inducing properties in cisplatin-resistant neuroblastoma cells."],"pmcid":["PMC10967698"],"pubmed_authors":["Sauer MJ","Prokop A","Buchele WRE","Gebendorfer AL","Kuhn FE","Pamperin J","Richter LF","Schlachta TP"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, characterization, and biomedical evaluation of ethylene-bridged tetra-NHC Pd(ii), Pt(ii) and Au(iii) complexes, with apoptosis-inducing properties in cisplatin-resistant neuroblastoma cells.","description":"Synthesis and characterization of the first two cyclic ethylene-bridged tetradentate NHC ligands, with an unsaturated (imidazole) and saturated backbone (2-imidazoline), are described. Complexes of both ligands containing palladium(ii) have been obtained. For platinum(ii) and gold(iii), only the unsaturated tetracarbene complexes could be isolated. The attempts to synthesize a methylene-bridged 2-imidazoline macrocycle are also described. Furthermore, a novel bisimidazolinium ligand precursor and its open-chain Pd<sup>II</sup> and Pt<sup>II</sup> tetracarbene complexes are obtained. Finally, it is shown that the unsaturated gold(iii) tetracarbene is able to induce apoptosis in malignant SK-N-AS neuroblastoma cells <i>via</i> the mitochondrial and ROS pathway and overcomes resistance to cisplatin <i>in vitro</i>.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T23:53:48.407Z","creation":"2025-04-04T23:53:48.407Z"},"accession":"S-EPMC10967698","cross_references":{"pubmed":["38544944"],"doi":["10.1039/d4ra01195c"]}}