biostudies-literatureBenz RDeutsche Forschungsgemeinschaft303https://www.ebi.ac.uk/biostudies/studies/S-EPMC10967727biostudies-literatureUnknown14(3)Mitochondria are most likely descendants of strictly aerobic prokaryotes from the class <i>Alphaproteobacteria</i>. The mitochondrial matrix is surrounded by two membranes according to its relationship with Gram-negative bacteria. Similar to the bacterial outer membrane, the mitochondrial outer membrane acts as a molecular sieve because it also contains diffusion pores. However, it is more actively involved in mitochondrial metabolism because it plays a functional role, whereas the bacterial outer membrane has only passive sieving properties. Mitochondrial porins, also known as eukaryotic porins or voltage-dependent anion-selective channels (VDACs) control the permeability properties of the mitochondrial outer membrane. They contrast with most bacterial porins because they are voltage-depeBiomoleculesSolute Transport through Mitochondrial Porins In Vitro and In Vivo.PMC10967727Be 865 16-2Benz RfalseSolute Transport through Mitochondrial Porins In Vitro and In Vivo.Mitochondria are most likely descendants of strictly aerobic prokaryotes from the class <i>Alphaproteobacteria</i>. The mitochondrial matrix is surrounded by two membranes according to its relationship with Gram-negative bacteria. Similar to the bacterial outer membrane, the mitochondrial outer membrane acts as a molecular sieve because it also contains diffusion pores. However, it is more actively involved in mitochondrial metabolism because it plays a functional role, whereas the bacterial outer membrane has only passive sieving properties. Mitochondrial porins, also known as eukaryotic porins or voltage-dependent anion-selective channels (VDACs) control the permeability properties of the mitochondrial outer membrane. They contrast with most bacterial porins because they are voltage-depe2024-01-01T00:00:00Z2024 Mar2025-04-21T21:27:22.425Z2025-04-05T18:22:09.795ZS-EPMC109677273854072310.3390/biom14030303