{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eggenhuizen PJ"],"funding":["Monash Health","Monash Health Foundation COVID-19 Research Fund","Australian Government Research Training Program (RTP) scholarship","Australian Government"],"pagination":["564"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10967880"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["Memory T cells form from the adaptive immune response to historic infections or vaccinations. Some memory T cells have the potential to recognise unrelated pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and generate cross-reactive immune responses. Notably, such T cell cross-reactivity has been observed between SARS-CoV-2 and other human coronaviruses. T cell cross-reactivity has also been observed between SARS-CoV-2 variants from unrelated microbes and unrelated vaccinations against influenza A, tuberculosis and measles, mumps and rubella. Extensive research and debate is underway to understand the mechanism and role of T cell cross-reactivity and how it relates to Coronavirus disease 2019 (COVID-19) outcomes. Here, we review the evidence for the ability of pre-existing memory T cells to cross-react with SARS-CoV-2. We discuss the latest findings on the impact of T cell cross-reactivity and the extent to which it can cross-protect from COVID-19."],"journal":["Biomedicines"],"pubmed_title":["The Influence of Cross-Reactive T Cells in COVID-19."],"pmcid":["PMC10967880"],"funding_grant_id":["NA","Research Training Program"],"pubmed_authors":["Eggenhuizen PJ","Ooi JD"],"additional_accession":[]},"is_claimable":false,"name":"The Influence of Cross-Reactive T Cells in COVID-19.","description":"Memory T cells form from the adaptive immune response to historic infections or vaccinations. Some memory T cells have the potential to recognise unrelated pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and generate cross-reactive immune responses. Notably, such T cell cross-reactivity has been observed between SARS-CoV-2 and other human coronaviruses. T cell cross-reactivity has also been observed between SARS-CoV-2 variants from unrelated microbes and unrelated vaccinations against influenza A, tuberculosis and measles, mumps and rubella. Extensive research and debate is underway to understand the mechanism and role of T cell cross-reactivity and how it relates to Coronavirus disease 2019 (COVID-19) outcomes. Here, we review the evidence for the ability of pre-existing memory T cells to cross-react with SARS-CoV-2. We discuss the latest findings on the impact of T cell cross-reactivity and the extent to which it can cross-protect from COVID-19.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-21T21:30:57.359Z","creation":"2025-04-05T18:22:24.955Z"},"accession":"S-EPMC10967880","cross_references":{"pubmed":["38540178"],"doi":["10.3390/biomedicines12030564"]}}