{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun Y"],"funding":["Key Research and Development Project of Shandong Province","Taishan Young Scholar Project of Shandong Province","the Central Public-interest Scientific Institution Basal Research Fund","Central Public-interest Scientific Institution Basal Research Fund","National Key Research and Development Program of China"],"pagination":["141"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10967968"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["The sex chromosome, especially specific in one sex, generally determines sexual size dimorphism (SSD), a phenomenon with dimorphic sexual difference in the body size. For <i>Cynoglossus semilaevis</i>, a flatfish in China, although the importance of chromosome W and its specific gene <i>zbed1</i> in female-biased SSD have been suggested, its family members and regulation information are still unknown. At present, three <i>zbed1</i> copies gene were identified on chromosome W, with no gametologs. Phylogenetic analysis for the ZBED family revealed an existence of ZBED9 in the fish. Nine members were uncovered from <i>C. semilaevis</i>, clustering into three kinds, ZBED1, ZBED4 and ZBEDX, which is less than the eleven kinds of ZBED members in mammals. The predominant expression of <i>zbed1</i> in the female brain and pituitary tissues was further verified by qPCR. Transcription factor <i>c/ebpα</i> could significantly enhance the transcriptional activity of <i>zbed1</i> promoter, which is opposite to its effect on the male determinant factor-<i>dmrt1</i>. When <i>zbed1</i> was interfered with, <i>piwil1</i>, <i>esr2</i> and <i>wnt7b</i> were up-regulated, while cell-cycle-related genes, including <i>cdk4</i> and <i>ccng1,</i> were down-regulated. Thus, <i>zbed1</i> is involved in cell proliferation by regulating <i>esr2</i>, <i>piwil1</i>, cell cycle and the Wnt pathway. Further research on their interactions would be helpful to understand fish SSD."],"journal":["Biology"],"pubmed_title":["Three Copies of <i>zbed1</i> Specific in Chromosome W Are Essential for Female-Biased Sexual Size Dimorphism in <i>Cynoglossus semilaevis</i>."],"pmcid":["PMC10967968"],"funding_grant_id":["2021LZGC028","CAFS (2023TD20)","2021LZGC028, 2023ZLYS02","CAFS (2020TD23)","2022YFF1000303","2023ZLYS02","tsqn202211266"],"pubmed_authors":["Li X","Wang N","Mai J","Sun Y","Xu W","Wang J","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Three Copies of <i>zbed1</i> Specific in Chromosome W Are Essential for Female-Biased Sexual Size Dimorphism in <i>Cynoglossus semilaevis</i>.","description":"The sex chromosome, especially specific in one sex, generally determines sexual size dimorphism (SSD), a phenomenon with dimorphic sexual difference in the body size. For <i>Cynoglossus semilaevis</i>, a flatfish in China, although the importance of chromosome W and its specific gene <i>zbed1</i> in female-biased SSD have been suggested, its family members and regulation information are still unknown. At present, three <i>zbed1</i> copies gene were identified on chromosome W, with no gametologs. Phylogenetic analysis for the ZBED family revealed an existence of ZBED9 in the fish. Nine members were uncovered from <i>C. semilaevis</i>, clustering into three kinds, ZBED1, ZBED4 and ZBEDX, which is less than the eleven kinds of ZBED members in mammals. The predominant expression of <i>zbed1</i> in the female brain and pituitary tissues was further verified by qPCR. Transcription factor <i>c/ebpα</i> could significantly enhance the transcriptional activity of <i>zbed1</i> promoter, which is opposite to its effect on the male determinant factor-<i>dmrt1</i>. When <i>zbed1</i> was interfered with, <i>piwil1</i>, <i>esr2</i> and <i>wnt7b</i> were up-regulated, while cell-cycle-related genes, including <i>cdk4</i> and <i>ccng1,</i> were down-regulated. Thus, <i>zbed1</i> is involved in cell proliferation by regulating <i>esr2</i>, <i>piwil1</i>, cell cycle and the Wnt pathway. Further research on their interactions would be helpful to understand fish SSD.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-21T21:29:02.312Z","creation":"2025-04-05T18:20:48.174Z"},"accession":"S-EPMC10967968","cross_references":{"pubmed":["38534411"],"doi":["10.3390/biology13030141"]}}