{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(5)"],"submitter":["Li J"],"pubmed_abstract":["Psoriasis is a chronic inflammatory proliferative dermatological ailment that currently lacks a definitive cure. Employing data mining techniques, this study identified a collection of substantially downregulated miRNAs (top 10). Notably, 32 targets were implicated in both the activation of the IL-17 signaling pathway and cell cycle dysregulation. <i>In silico</i> analysis revealed that one of these miRNAs, miR-26a-5p, is a highly conserved cross-species miRNA. Strikingly, the miR-26a-5p sequences in humans and mice are identical, and mmu-miR-26a-5p was found to target the same 7 cell cycle targets as its human counterpart, hsa-miR-26a-5p. Among these targets, CDC6 and CCNE1 were the most effective targets of miR-26a-5p, which was further validated <i>in vitro</i> using a dual luciferase r"],"journal":["Aging"],"pagination":["4631-4653"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10968694"],"repository":["biostudies-literature"],"pubmed_title":["miR-26a-5p inhibits the proliferation of psoriasis-like keratinocytes <i>in vitro</i> and <i>in vivo</i> by dual interference with the CDC6/CCNE1 axis."],"pmcid":["PMC10968694"],"pubmed_authors":["Pang D","Zhou L","Li J","Ouyang H","Tian Y","Yu H"],"additional_accession":[]},"is_claimable":false,"name":"miR-26a-5p inhibits the proliferation of psoriasis-like keratinocytes <i>in vitro</i> and <i>in vivo</i> by dual interference with the CDC6/CCNE1 axis.","description":"Psoriasis is a chronic inflammatory proliferative dermatological ailment that currently lacks a definitive cure. Employing data mining techniques, this study identified a collection of substantially downregulated miRNAs (top 10). Notably, 32 targets were implicated in both the activation of the IL-17 signaling pathway and cell cycle dysregulation. <i>In silico</i> analysis revealed that one of these miRNAs, miR-26a-5p, is a highly conserved cross-species miRNA. Strikingly, the miR-26a-5p sequences in humans and mice are identical, and mmu-miR-26a-5p was found to target the same 7 cell cycle targets as its human counterpart, hsa-miR-26a-5p. Among these targets, CDC6 and CCNE1 were the most effective targets of miR-26a-5p, which was further validated <i>in vitro</i> using a dual luciferase r","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T20:07:04.112Z","creation":"2025-04-04T23:52:58.514Z"},"accession":"S-EPMC10968694","cross_references":{"pubmed":["38446584"],"doi":["10.18632/aging.205618"]}}