biostudies-literatureZhang CBasic Research Project of Henan Eye InstituteBasic Research Project of the Henan Eye InstituteNational Natural Science Foundation of ChinaHealth science and Technology Innovation Outstanding Young talents training program of Henan ProvinceHealth Science and Technology Innovation Outstanding Young Talents Training Program of Henan Province158https://www.ebi.ac.uk/biostudies/studies/S-EPMC10970420biostudies-literatureUnknown10(3)Age-related macular degeneration (AMD) is an ocular disease that leads to progressive photoreceptor death and visual impairment. Currently, the most common therapeutic strategy is to deliver anti-vascular endothelial growth factor (anti-VEGF) agents into the eyes of patients with wet AMD. However, this treatment method requires repeated injections, which potentially results in surgical complications and unwanted side effects for patients. An effective therapeutic approach for dry AMD also remains elusive. Therefore, there is a surge of enthusiasm for the developing the biodegradable drug delivery systems with sustained release capability and develop a promising therapeutic strategy. Notably, the strides made in hydrogels which possess intricate three-dimensional polymer networks have profoGels (Basel, Switzerland)Hydrogel-Based Therapy for Age-Related Macular Degeneration: Current Innovations, Impediments, and Future Perspectives.PMC10970420No. 82101162YXKC2021027No. 21JCQN002 and 21JCZD002No. YXKC20210278210116221JCZD00221JCQN002Fan WLi SWei DTao YZhang CWang JSong ZWu HfalseHydrogel-Based Therapy for Age-Related Macular Degeneration: Current Innovations, Impediments, and Future Perspectives.Age-related macular degeneration (AMD) is an ocular disease that leads to progressive photoreceptor death and visual impairment. Currently, the most common therapeutic strategy is to deliver anti-vascular endothelial growth factor (anti-VEGF) agents into the eyes of patients with wet AMD. However, this treatment method requires repeated injections, which potentially results in surgical complications and unwanted side effects for patients. An effective therapeutic approach for dry AMD also remains elusive. Therefore, there is a surge of enthusiasm for the developing the biodegradable drug delivery systems with sustained release capability and develop a promising therapeutic strategy. Notably, the strides made in hydrogels which possess intricate three-dimensional polymer networks have profo2024-01-01T00:00:00Z2024 Feb2025-04-21T21:28:54.299Z2025-04-05T18:22:24.241ZS-EPMC109704203853457610.3390/gels10030158