{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["271(4)"],"submitter":["Wiemann M"],"funding":["Universitätsmedizin Greifswald"],"pubmed_abstract":["<h4>Background</h4>Neuroinflammation and maladaptive neuroplasticity play pivotal roles in migraine (MIG), trigeminal autonomic cephalalgias (TAC), and complex regional pain syndrome (CRPS). Notably, CRPS shares connections with calcitonin gene-related peptide (CGRP) in its pathophysiology. This study aims to assess if the documented links between CRPS and MIG/TAC in literature align with clinical phenotypes and disease progressions. This assessment may bolster the hypothesis of shared pathophysiological mechanisms.<h4>Methods</h4>Patients with CRPS (n = 184) and an age-/gender-matched control group with trauma but without CRPS (n = 148) participated in this case-control study. Participant answered well-established questionnaires for the definition of CRPS symptoms, any headache complaints"],"journal":["Journal of neurology"],"pagination":["1850-1860"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10972976"],"repository":["biostudies-literature"],"pubmed_title":["Evidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case-control study."],"pmcid":["PMC10972976"],"pubmed_authors":["Fleischmann R","Naegel S","Strauss S","Zimowski N","Wiemann M","Blendow SL","Enax-Krumova E"],"additional_accession":[]},"is_claimable":false,"name":"Evidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case-control study.","description":"<h4>Background</h4>Neuroinflammation and maladaptive neuroplasticity play pivotal roles in migraine (MIG), trigeminal autonomic cephalalgias (TAC), and complex regional pain syndrome (CRPS). Notably, CRPS shares connections with calcitonin gene-related peptide (CGRP) in its pathophysiology. This study aims to assess if the documented links between CRPS and MIG/TAC in literature align with clinical phenotypes and disease progressions. This assessment may bolster the hypothesis of shared pathophysiological mechanisms.<h4>Methods</h4>Patients with CRPS (n = 184) and an age-/gender-matched control group with trauma but without CRPS (n = 148) participated in this case-control study. Participant answered well-established questionnaires for the definition of CRPS symptoms, any headache complaints","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-26T11:23:16.12Z","creation":"2025-04-06T13:42:10.578Z"},"accession":"S-EPMC10972976","cross_references":{"pubmed":["38070030"],"doi":["10.1007/s00415-023-12119-w"]}}