biostudies-literatureUnknown271(4)Wiemann MUniversitätsmedizin Greifswald<h4>Background</h4>Neuroinflammation and maladaptive neuroplasticity play pivotal roles in migraine (MIG), trigeminal autonomic cephalalgias (TAC), and complex regional pain syndrome (CRPS). Notably, CRPS shares connections with calcitonin gene-related peptide (CGRP) in its pathophysiology. This study aims to assess if the documented links between CRPS and MIG/TAC in literature align with clinical phenotypes and disease progressions. This assessment may bolster the hypothesis of shared pathophysiological mechanisms.<h4>Methods</h4>Patients with CRPS (n = 184) and an age-/gender-matched control group with trauma but without CRPS (n = 148) participated in this case-control study. Participant answered well-established questionnaires for the definition of CRPS symptoms, any headache complaintsJournal of neurology1850-1860https://www.ebi.ac.uk/biostudies/studies/S-EPMC10972976biostudies-literatureEvidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case-control study.PMC10972976Fleischmann RNaegel SStrauss SZimowski NWiemann MBlendow SLEnax-Krumova EfalseEvidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case-control study.<h4>Background</h4>Neuroinflammation and maladaptive neuroplasticity play pivotal roles in migraine (MIG), trigeminal autonomic cephalalgias (TAC), and complex regional pain syndrome (CRPS). Notably, CRPS shares connections with calcitonin gene-related peptide (CGRP) in its pathophysiology. This study aims to assess if the documented links between CRPS and MIG/TAC in literature align with clinical phenotypes and disease progressions. This assessment may bolster the hypothesis of shared pathophysiological mechanisms.<h4>Methods</h4>Patients with CRPS (n = 184) and an age-/gender-matched control group with trauma but without CRPS (n = 148) participated in this case-control study. Participant answered well-established questionnaires for the definition of CRPS symptoms, any headache complaints2024-01-01T00:00:00Z2024 Apr2025-04-26T11:23:16.12Z2025-04-06T13:42:10.578ZS-EPMC109729763807003010.1007/s00415-023-12119-w