{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Zhao H"],"pubmed_abstract":["<b>Introduction:</b> Some herbal ingredients can reshape the composition of the gut microbiome as well as its metabolites. At the same time, the gut microbiota can also affect drug metabolism. A large number of studies have reported that saponins are biotransformed under the action of intestinal microorganisms to improve drug efficacy and bioavailability. Capilliposide A is a triterpenoid saponin, which is derived from Lysimachia <i>capillipes</i> Hemsl. CPS-A has anti-inflammatory pharmacological activity, but the substance basis <i>in vivo</i> is unknown at present, so studies on the interaction between intestinal microorganisms and CPS-A may clarify the pharmacodynamic substance basis of CPS-A. <b>Methods:</b> This study established a colitis mouse model, collected sterile feces from no"],"journal":["Frontiers in pharmacology"],"pagination":["1361643"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10973126"],"repository":["biostudies-literature"],"pubmed_title":["In-depth LC-MS and <i>in-vitro</i> studies of a triterpenoid saponin capilliposide-A metabolism modulation in gut microbiota of mice."],"pmcid":["PMC10973126"],"pubmed_authors":["Tian J","Li X","Fang J","Lin B","Hu X","Zhang X","Guan S","Cai J","Zhu W","He Q","Jin J","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"In-depth LC-MS and <i>in-vitro</i> studies of a triterpenoid saponin capilliposide-A metabolism modulation in gut microbiota of mice.","description":"<b>Introduction:</b> Some herbal ingredients can reshape the composition of the gut microbiome as well as its metabolites. At the same time, the gut microbiota can also affect drug metabolism. A large number of studies have reported that saponins are biotransformed under the action of intestinal microorganisms to improve drug efficacy and bioavailability. Capilliposide A is a triterpenoid saponin, which is derived from Lysimachia <i>capillipes</i> Hemsl. CPS-A has anti-inflammatory pharmacological activity, but the substance basis <i>in vivo</i> is unknown at present, so studies on the interaction between intestinal microorganisms and CPS-A may clarify the pharmacodynamic substance basis of CPS-A. <b>Methods:</b> This study established a colitis mouse model, collected sterile feces from no","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-16T00:10:57.924Z","creation":"2025-04-06T13:39:57.633Z"},"accession":"S-EPMC10973126","cross_references":{"pubmed":["38549666"],"doi":["10.3389/fphar.2024.1361643"]}}