biostudies-literatureUnknown14(1)Levy BPHRC<h4>Background</h4>Reliable predictors of outcomes in venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy are limited. While elevated lactate levels over time have been linked to outcomes in cardiogenic shock (CS), their significance in VA-ECMO-treated patients remains inconclusive.<h4>Methods</h4>We conducted a post hoc analysis of data from the HYPO-ECMO trial, which compared normothermia to moderate hypothermia in CS patients supported by VA-ECMO. We examined daily lactate levels collected over a week to assess their correlation with 30-day mortality.<h4>Results</h4>Among the 318 out of 334 patients (95%) with baseline lactate measurements, 66 had normal levels (< 2.2 mmol/l, 21%). No difference was found in lactate course between moderate hypothermia and normothermia groAnnals of intensive care43https://www.ebi.ac.uk/biostudies/studies/S-EPMC10973308biostudies-literatureSerial daily lactate levels association with 30-day outcome in cardiogenic shock patients treated with VA-ECMO: a post-hoc analysis of the HYPO-ECMO study.PMC10973308Duarte KBakker JLevy BKimmoun ACuau SGirerd NBaudry GHYPO-ECMO trial group and the International ECMO Network (ECMONet)falseSerial daily lactate levels association with 30-day outcome in cardiogenic shock patients treated with VA-ECMO: a post-hoc analysis of the HYPO-ECMO study.<h4>Background</h4>Reliable predictors of outcomes in venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy are limited. While elevated lactate levels over time have been linked to outcomes in cardiogenic shock (CS), their significance in VA-ECMO-treated patients remains inconclusive.<h4>Methods</h4>We conducted a post hoc analysis of data from the HYPO-ECMO trial, which compared normothermia to moderate hypothermia in CS patients supported by VA-ECMO. We examined daily lactate levels collected over a week to assess their correlation with 30-day mortality.<h4>Results</h4>Among the 318 out of 334 patients (95%) with baseline lactate measurements, 66 had normal levels (< 2.2 mmol/l, 21%). No difference was found in lactate course between moderate hypothermia and normothermia gro2024-01-01T00:00:00Z2024 Mar2026-07-15T14:04:02.363Z2025-04-05T23:16:39.898ZS-EPMC109733083853653410.1186/s13613-024-01266-6