biostudies-literatureAhsan HVetenskapsrådetLund UniversityRagnar Söderbergs stiftelse7292https://www.ebi.ac.uk/biostudies/studies/S-EPMC10973500biostudies-literatureUnknown14(1)Glioblastoma multiforme (GBM) IDH-wildtype is the most prevalent brain malignancy in adults. However, molecular mechanisms, which leads to GBM have not been completely elucidated. Granulocyte colony-stimulating factor (GCSF), Granulocyte colony-stimulating factor receptor GCSFR, and Signal transducers and activators of transcription 3 (STAT3) have been involved in the occurrence and development of various cancers, but their role in GBM is little known. Herein, we have investigated the gene and protein expression of GCSF, GCSFR, and STAT3 in 21 tissue biopsy samples and also in tumor associated normal tissue (TANT) samples derived from glioblastoma patients, which revealed significantly differential expression of these genes. To validate our findings, we performed a comprehensive integratedScientific reportsPotential diagnostic and drug target markers in glioblastoma.PMC109735002018-022662018‐02266M13/18Asghar MMalik SIAhsan HfalsePotential diagnostic and drug target markers in glioblastoma.Glioblastoma multiforme (GBM) IDH-wildtype is the most prevalent brain malignancy in adults. However, molecular mechanisms, which leads to GBM have not been completely elucidated. Granulocyte colony-stimulating factor (GCSF), Granulocyte colony-stimulating factor receptor GCSFR, and Signal transducers and activators of transcription 3 (STAT3) have been involved in the occurrence and development of various cancers, but their role in GBM is little known. Herein, we have investigated the gene and protein expression of GCSF, GCSFR, and STAT3 in 21 tissue biopsy samples and also in tumor associated normal tissue (TANT) samples derived from glioblastoma patients, which revealed significantly differential expression of these genes. To validate our findings, we performed a comprehensive integrated2024-01-01T00:00:00Z2024 Mar2025-04-21T21:30:20.856Z2025-04-05T18:22:55.434ZS-EPMC109735003853869110.1038/s41598-024-57752-1