{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gonzalez JS"],"funding":["NCATS NIH HHS","Centers for Disease Control and Prevention","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","NIMHD NIH HHS","American Diabetes Association","NIGMS NIH HHS","CDC HHS"],"pagination":["610-619"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10973899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(4)"],"pubmed_abstract":["<h4>Objective</h4>We evaluated whether adding basal insulin to metformin in adults with early type 2 diabetes mellitus (T2DM) would increase emotional distress relative to other treatments.<h4>Research design and methods</h4>The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) of adults with T2DM of <10 years' duration, HbA1c 6.8-8.5%, and taking metformin monotherapy randomly assigned participants to add insulin glargine U-100, sulfonylurea glimepiride, the glucagon-like peptide-1 receptor agonist liraglutide, or the dipeptidyl peptidase 4 inhibitor sitagliptin. The Emotional Distress Substudy enrolled 1,739 GRADE participants (mean [SD] age 58.0 [10.2] years, 32% female, 56% non-Hispanic White, 18% non-Hispanic Black, 17% Hispanic) and assessed diabete"],"journal":["Diabetes care"],"pubmed_title":["Differential Effects of Type 2 Diabetes Treatment Regimens on Diabetes Distress and Depressive Symptoms in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)."],"pmcid":["PMC10973899"],"funding_grant_id":["R01DK104845","UL1 TR002378","UM1 TR004528","UL1 TR001102","UL1 TR002537","P30 DK111022","UL1 TR001425","UL1 TR002535","UL1 TR000439","UL1 TR001108","UL1 TR001449","UL1 TR001409","P30 DK020572","U01DK098246","R01 DK104845","UL1 TR002243","P30 DK092926","UL1 TR002489","UL1 TR002345","UL1 TR002541","P50 MD017338","UL1 TR002548","U54 GM104940","P30 DK017047","UL1 TR000445","UL1 TR002529","U34DK088043","U34 DK088043","P30 DK072476","U01 DK098246","P30 DK079626","P30 DK020541","UL1 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T2DM of <10 years' duration, HbA1c 6.8-8.5%, and taking metformin monotherapy randomly assigned participants to add insulin glargine U-100, sulfonylurea glimepiride, the glucagon-like peptide-1 receptor agonist liraglutide, or the dipeptidyl peptidase 4 inhibitor sitagliptin. The Emotional Distress Substudy enrolled 1,739 GRADE participants (mean [SD] age 58.0 [10.2] years, 32% female, 56% non-Hispanic White, 18% non-Hispanic Black, 17% Hispanic) and assessed diabete","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-21T21:27:34.327Z","creation":"2025-04-05T18:25:30.886Z"},"accession":"S-EPMC10973899","cross_references":{"pubmed":["38416773"],"doi":["10.2337/dc23-2459"]}}