{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garvey WT"],"funding":["NCATS NIH HHS","Centers for Disease Control and Prevention","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","American Diabetes Association","NIGMS NIH HHS","CDC HHS"],"pagination":["562-570"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10973909"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(4)"],"pubmed_abstract":["<h4>Objective</h4>To describe the individual and joint associations of baseline factors with glycemia, and also with differential effectiveness of medications added to metformin.<h4>Research design and methods</h4>Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants (with type 2 diabetes diagnosed for <10 years, on metformin, and with HbA1c 6.8-8.5%; N = 5,047) were randomly assigned to a basal insulin (glargine), sulfonylurea (glimepiride), glucagon-like peptide 1 agonist (liraglutide), or dipeptidyl peptidase 4 inhibitor (sitagliptin). The glycemic outcome was HbA1c ≥7.0%, subsequently confirmed. Univariate and multivariate regression and classification and regression tree (CART) analyses were used to assess the association of baseline factors"],"journal":["Diabetes care"],"pubmed_title":["Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial."],"pmcid":["PMC10973909"],"funding_grant_id":["UM1 TR004528","UL1 TR002378","UL1 TR002537","UL1 TR002535","UL1 TR000439","UL1 TR001108","UL1 TR001449","UL1 TR001409","U01DK098246","P30 DK020572","U34-DK-088043","UL1 TR002243","P30 DK092926","UL1 TR002489","UL1 TR002345","UL1 TR002548","P30 DK017047","U54 GM104940","UL1 TR000445","UL1 TR002529","U34 DK088043","P30 DK072476","U01 DK098246","P30 DK079626","P30 DK020541"],"pubmed_authors":["Estrada L","Pucchetti B","Schield E","Petrovitch H","Utzschneider KM","Alfano L","Rassouli N","Hollander PA","Ressing A","Rhothisen S","Kuechenmeister L","Ngo L","DeManbey A","Bahtiyar G","Burgess E","Schnurr-Breen L","Magee M","Cherrington 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V","Seipel K","Zimmer RP","Steffes M","Aroda V","Campbell C","Morales Gomez B","Fuller G","Pirics V","Kumar A","Ghioni D","Mather KJ"],"additional_accession":[]},"is_claimable":false,"name":"Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial.","description":"<h4>Objective</h4>To describe the individual and joint associations of baseline factors with glycemia, and also with differential effectiveness of medications added to metformin.<h4>Research design and methods</h4>Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants (with type 2 diabetes diagnosed for <10 years, on metformin, and with HbA1c 6.8-8.5%; N = 5,047) were randomly assigned to a basal insulin (glargine), sulfonylurea (glimepiride), glucagon-like peptide 1 agonist (liraglutide), or dipeptidyl peptidase 4 inhibitor (sitagliptin). The glycemic outcome was HbA1c ≥7.0%, subsequently confirmed. Univariate and multivariate regression and classification and regression tree (CART) analyses were used to assess the association of baseline factors","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-21T21:30:30.237Z","creation":"2025-04-05T18:21:24.633Z"},"accession":"S-EPMC10973909","cross_references":{"pubmed":["38285957"],"doi":["10.2337/dc23-1782"]}}