{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goo J"],"funding":["Ministry of Science and ICT","National Research Council of Science and Technology","KIST Institutional Program","Ministry of Health and Welfare","National Research Foundation of Korea"],"pagination":["311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10974516"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(3)"],"pubmed_abstract":["Small Extracellular Vesicles (sEVs) are typically 30-150 nm in diameter, produced inside cells, and released into the extracellular space. These vesicles carry RNA, DNA, proteins, and lipids that reflect the characteristics of their parent cells, enabling communication between cells and the alteration of functions or differentiation of target cells. Owing to these properties, sEVs have recently gained attention as potential carriers for functional molecules and drug delivery tools. However, their use as a therapeutic platform faces limitations, such as challenges in mass production, purity issues, and the absence of established protocols and characterization methods. To overcome these, researchers are exploring the characterization and engineering of sEVs for various applications. This rev"],"journal":["Pharmaceutics"],"pubmed_title":["Extracellular Vesicles in Therapeutics: A Comprehensive Review on Applications, Challenges, and Clinical Progress."],"pmcid":["PMC10974516"],"funding_grant_id":["2023-00262155","HI22C1501",". 2021-0-02076","RS-2023-00266133","2V09840-23-P038 (ISK) and 2E33132 (CJ)","2021R1A2C1095046","2017R1A3B1023418"],"pubmed_authors":["Jeong C","Lee J","Lee Y","Goo J","Kim IS"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular Vesicles in Therapeutics: A Comprehensive Review on Applications, Challenges, and Clinical Progress.","description":"Small Extracellular Vesicles (sEVs) are typically 30-150 nm in diameter, produced inside cells, and released into the extracellular space. These vesicles carry RNA, DNA, proteins, and lipids that reflect the characteristics of their parent cells, enabling communication between cells and the alteration of functions or differentiation of target cells. Owing to these properties, sEVs have recently gained attention as potential carriers for functional molecules and drug delivery tools. However, their use as a therapeutic platform faces limitations, such as challenges in mass production, purity issues, and the absence of established protocols and characterization methods. To overcome these, researchers are exploring the characterization and engineering of sEVs for various applications. This rev","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-21T21:25:55.316Z","creation":"2025-04-05T18:24:46.294Z"},"accession":"S-EPMC10974516","cross_references":{"pubmed":["38543204"],"doi":["10.3390/pharmaceutics16030311"]}}