{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye Y"],"funding":["the Natural Science Foundation of Zhejiang Province"],"pagination":["1375"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10974559"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(6)"],"pubmed_abstract":["<i>Artemisia japonica</i> Thunb. has been used as a traditional Chinese medicine and a vegetable for thousands of years in China. However, there are few reports on the chemical composition and biological activity of its leaves. Thus, this study aimed to evaluate the chemical composition, antioxidant and anti-inflammatory effects of water extracts of <i>A. japonica</i> leaves and their underlying mechanisms. A total of 48 compounds were identified in the water extract using UPLC-QTOF-MS<sup>2</sup> analysis, with phenolic acids, particularly chlorogenic acid compounds, being the predominant components. The ethyl acetate fraction (EAF) contained most of the total phenolic content (385.4217 mg GAE/g) and displayed superior antioxidant capacity with the IC<sub>50DPPH•</sub>, IC<sub>50ABTS•+</s"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["The Extracts Derived from <i>Artemisia japonica</i> Thunb. Leaves Mitigate Oxidative Stress and Inflammatory Response Induced by LPS in RAW264.7 Cells through Modulation of the Nrf2/HO-1 Signaling Pathway."],"pmcid":["PMC10974559"],"funding_grant_id":["grant number: LY23H280004"],"pubmed_authors":["Li X","Li S","Jiang F","Chen M","Zhang X","Wang X","Ye Y","Zhang C","Li M"],"additional_accession":[]},"is_claimable":false,"name":"The Extracts Derived from <i>Artemisia japonica</i> Thunb. Leaves Mitigate Oxidative Stress and Inflammatory Response Induced by LPS in RAW264.7 Cells through Modulation of the Nrf2/HO-1 Signaling Pathway.","description":"<i>Artemisia japonica</i> Thunb. has been used as a traditional Chinese medicine and a vegetable for thousands of years in China. However, there are few reports on the chemical composition and biological activity of its leaves. Thus, this study aimed to evaluate the chemical composition, antioxidant and anti-inflammatory effects of water extracts of <i>A. japonica</i> leaves and their underlying mechanisms. A total of 48 compounds were identified in the water extract using UPLC-QTOF-MS<sup>2</sup> analysis, with phenolic acids, particularly chlorogenic acid compounds, being the predominant components. The ethyl acetate fraction (EAF) contained most of the total phenolic content (385.4217 mg GAE/g) and displayed superior antioxidant capacity with the IC<sub>50DPPH•</sub>, IC<sub>50ABTS•+</s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-26T11:14:22.663Z","creation":"2025-04-06T13:40:03.254Z"},"accession":"S-EPMC10974559","cross_references":{"pubmed":["38543011"],"doi":["10.3390/molecules29061375"]}}