{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao JK"],"funding":["Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province","Yantai \"Double Hundred Plan\"","The Graduate Innovation Foundation of Yantai University","the Foundation of Anhui Laboratory of Molecule-Based Materials"],"pagination":["1202"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10974807"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(6)"],"pubmed_abstract":["A practical metal-free and additive-free approach for the synthesis of 6/7/8-membered oxacyclic ketone-fused isoxazoles/isoxazolines tetracyclic or tricyclic structures is reported through C<sub>sp</sub><sup>3</sup>-H bond radical nitrile oxidation and the intramolecular cycloaddition of alkenyl/alkynyl-substituted aryl methyl ketones. This convenient approach enables the simultaneous formation of isoxazole/isoxazoline and 6/7/8-membered oxacyclic ketones to form polycyclic architectures by using <i>tert</i>-butyl nitrite (TBN) as a non-metallic radical initiator and N-O fragment donor."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["<i>tert</i>-Butyl Nitrite-Induced Radical Nitrile Oxidation Cycloaddition: Synthesis of Isoxazole/Isoxazoline-Fused Benzo 6/7/8-membered Oxacyclic Ketones."],"pmcid":["PMC10974807"],"funding_grant_id":["no","fzj22022","KGIFYTU2312"],"pubmed_authors":["Zhang HX","Sun YY","Li YC","Yue QW","Zhu YP","Yang CM","Ma Y","Dong QK","Cao TZ","Cao JK"],"additional_accession":[]},"is_claimable":false,"name":"<i>tert</i>-Butyl Nitrite-Induced Radical Nitrile Oxidation Cycloaddition: Synthesis of Isoxazole/Isoxazoline-Fused Benzo 6/7/8-membered Oxacyclic Ketones.","description":"A practical metal-free and additive-free approach for the synthesis of 6/7/8-membered oxacyclic ketone-fused isoxazoles/isoxazolines tetracyclic or tricyclic structures is reported through C<sub>sp</sub><sup>3</sup>-H bond radical nitrile oxidation and the intramolecular cycloaddition of alkenyl/alkynyl-substituted aryl methyl ketones. This convenient approach enables the simultaneous formation of isoxazole/isoxazoline and 6/7/8-membered oxacyclic ketones to form polycyclic architectures by using <i>tert</i>-butyl nitrite (TBN) as a non-metallic radical initiator and N-O fragment donor.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-22T21:32:37.952Z","creation":"2025-04-06T03:34:17.961Z"},"accession":"S-EPMC10974807","cross_references":{"pubmed":["38542839"],"doi":["10.3390/molecules29061202"]}}