biostudies-literatureUnknown12(3)Comunale BA<b>Introduction:</b> Prior research explores whether seasonal and childhood vaccines mitigate the risk of SARS-CoV-2 infection. Although there are trials investigating COVID-19 infection in response to the effects of the oral poliovirus vaccine (OPV), there has been no prior research assessing COVID-19 outcomes in recently immunized adults with the inactivated poliovirus vaccine (IPV). <b>Methods:</b> SARS-CoV-2 infection and COVID-19 symptoms were analyzed across a cohort of 282 adults who received an IPV booster. Bivariate and multivariate regression models explored associations among variables related to vaccination histories and COVID-19 outcomes. <b>Results:</b> One year post-IPV inoculation, participants who had never received OPV were more likely to test positive for SARS-CoV-2 and Vaccines219https://www.ebi.ac.uk/biostudies/studies/S-EPMC10974902biostudies-literatureInactivated Poliovirus Vaccine Booster Reduces the Likelihood of COVID-19 Outcomes in Individuals Primed with Oral Poliovirus Vaccination.PMC10974902Hsu YJLarson RJEngineer LDAzodoh CSingh AJackson-Ward EComunale BAfalseInactivated Poliovirus Vaccine Booster Reduces the Likelihood of COVID-19 Outcomes in Individuals Primed with Oral Poliovirus Vaccination.<b>Introduction:</b> Prior research explores whether seasonal and childhood vaccines mitigate the risk of SARS-CoV-2 infection. Although there are trials investigating COVID-19 infection in response to the effects of the oral poliovirus vaccine (OPV), there has been no prior research assessing COVID-19 outcomes in recently immunized adults with the inactivated poliovirus vaccine (IPV). <b>Methods:</b> SARS-CoV-2 infection and COVID-19 symptoms were analyzed across a cohort of 282 adults who received an IPV booster. Bivariate and multivariate regression models explored associations among variables related to vaccination histories and COVID-19 outcomes. <b>Results:</b> One year post-IPV inoculation, participants who had never received OPV were more likely to test positive for SARS-CoV-2 and 2024-01-01T00:00:00Z2024 Feb2026-04-08T15:24:05.429Z2025-04-05T23:18:29.405ZS-EPMC109749023854385310.3390/vaccines12030219