biostudies-literatureUnknown13(3)Barco GThe possible future emergence of new SARS-CoV-2 virus variants pushes the development of new chemoprophylaxis protocols complementary to the unspecific and specific immune-prophylaxis measures currently used. The SARS-CoV-2 virus is particularly sensitive to oxidation, due to the relevant positive electrical charge of its spike protein used as a ligand for target cells. The present study evaluated the safety and efficacy of a new oxidant preparation, liquid hyperoxygen (IOL), to neutralize the SARS-CoV-2 virus. IOL was incubated with throat swabs containing a human-type virus. The samples were then incubated with cells expressing the ACE2 receptor and, therefore, very sensitive to SARS-CoV-2 infection. The ability to neutralize SARS-CoV-2 was determined by assessing the amount of viral nucPathogens (Basel, Switzerland)244https://www.ebi.ac.uk/biostudies/studies/S-EPMC10974922biostudies-literatureIndoor Inactivation of SARS-CoV-2 Virus by Liquid Hyperoxygen.PMC10974922Barco GPrati UKhalid ZPulliero AAngelinetta CIzzotti AfalseIndoor Inactivation of SARS-CoV-2 Virus by Liquid Hyperoxygen.The possible future emergence of new SARS-CoV-2 virus variants pushes the development of new chemoprophylaxis protocols complementary to the unspecific and specific immune-prophylaxis measures currently used. The SARS-CoV-2 virus is particularly sensitive to oxidation, due to the relevant positive electrical charge of its spike protein used as a ligand for target cells. The present study evaluated the safety and efficacy of a new oxidant preparation, liquid hyperoxygen (IOL), to neutralize the SARS-CoV-2 virus. IOL was incubated with throat swabs containing a human-type virus. The samples were then incubated with cells expressing the ACE2 receptor and, therefore, very sensitive to SARS-CoV-2 infection. The ability to neutralize SARS-CoV-2 was determined by assessing the amount of viral nuc2024-01-01T00:00:00Z2024 Mar2025-04-22T21:31:10.876Z2025-04-06T03:34:20.081ZS-EPMC109749223853558710.3390/pathogens13030244