biostudies-literaturePeng LStudy of Diet and Nutrition Assessment and Intervention Technology of National Key R&D ProgramDiet and Nutrition Assessment and Intervention TechnologyLong-term Health Effects Assessment Project of Infants and Toddlers Nutritional Pack792https://www.ebi.ac.uk/biostudies/studies/S-EPMC10975108biostudies-literatureUnknown16(6)<h4>Background</h4>Both genetics and vitamin D deficiency are associated with childhood obesity. However, the role of vitamin D status between polygenic and childhood obesity has been unknown. The current study aimed to determine the relation between genetic factors, vitamin D status, and BMI-for-age <i>z</i> score (zBMI) in Chinese preschool children.<h4>Methods</h4>A total of 1046 participants aged 3.7 to 6.6 years old from the Long-term Health Effects Assessment Project of Infants and Toddlers Nutritional Pack (LHEAPITNP) were included in this study. The polygenic risk score (PRS) was established based on 55 BMI-related single nucleotide polymorphisms (SNPs) derived from a published genome-wide association study (GWAS) for BMI. Serum 25(OH)D was used as an index of vitamin D status and measured with liquid chromatography-tandem mass spectrometry (LC/MS-MS) assay. The Wilcoxon test or Kruskal-Wallis test was used to compare the differences of variables between different groups and Spearman correlation analysis was used for analyzing the correlations between the PRS, 25(OH)D levels, and zBMI.<h4>Results</h4>The PRS showed a positive relation to zBMI (<i>r</i>_s = 0.0953, <i>p</i> = 0.0022) and 25(OH)D showed a negative relation to zBMI (<i>r</i>_s = -0.1082, <i>p</i> = 0.0005) in the full-adjustment model. In addition, the differences in zBMI at different vitamin D statuses in the low-risk PRS group and the intermediate-risk PRS group were both statistically significant (<i>p</i>_low = 0.0308, <i>p</i>_intermediate = 0.0121), the median zBMI was both higher at vitamin D insufficiency status. And the difference in zBMI between different genetic risk groups was also statistically significant at vitamin D sufficiency status (<i>p</i> = 0.0077). Furthermore, genetic risk showed a positive relation to zBMI at vitamin D sufficiency status, and the <i>p</i> for trend was 0.0028.<h4>Conclusions</h4>Our findings suggested that vitamin D was related to zBMI negatively in Chinese preschoolers and maintaining adequate vitamin D levels may only contribute to lower the zBMI in preschoolers with low and intermediate genetic susceptibility.NutrientsRelation between Polygenic Risk Score, Vitamin D Status and BMI-for-Age <i>z</i> Score in Chinese Preschool Children.PMC109751081310311070002000012020YFC2006301No.131031107000200001No.2020YFC2006301Wang MHuo JShi LLi YFeng JPeng LLiu THan CChen CGong ZZhao JZhuo QfalseRelation between Polygenic Risk Score, Vitamin D Status and BMI-for-Age <i>z</i> Score in Chinese Preschool Children.<h4>Background</h4>Both genetics and vitamin D deficiency are associated with childhood obesity. However, the role of vitamin D status between polygenic and childhood obesity has been unknown. The current study aimed to determine the relation between genetic factors, vitamin D status, and BMI-for-age <i>z</i> score (zBMI) in Chinese preschool children.<h4>Methods</h4>A total of 1046 participants aged 3.7 to 6.6 years old from the Long-term Health Effects Assessment Project of Infants and Toddlers Nutritional Pack (LHEAPITNP) were included in this study. The polygenic risk score (PRS) was established based on 55 BMI-related single nucleotide polymorphisms (SNPs) derived from a published genome-wide association study (GWAS) for BMI. Serum 25(OH)D was used as an index of vitamin D status and measured with liquid chromatography-tandem mass spectrometry (LC/MS-MS) assay. The Wilcoxon test or Kruskal-Wallis test was used to compare the differences of variables between different groups and Spearman correlation analysis was used for analyzing the correlations between the PRS, 25(OH)D levels, and zBMI.<h4>Results</h4>The PRS showed a positive relation to zBMI (<i>r</i>_s = 0.0953, <i>p</i> = 0.0022) and 25(OH)D showed a negative relation to zBMI (<i>r</i>_s = -0.1082, <i>p</i> = 0.0005) in the full-adjustment model. In addition, the differences in zBMI at different vitamin D statuses in the low-risk PRS group and the intermediate-risk PRS group were both statistically significant (<i>p</i>_low = 0.0308, <i>p</i>_intermediate = 0.0121), the median zBMI was both higher at vitamin D insufficiency status. And the difference in zBMI between different genetic risk groups was also statistically significant at vitamin D sufficiency status (<i>p</i> = 0.0077). Furthermore, genetic risk showed a positive relation to zBMI at vitamin D sufficiency status, and the <i>p</i> for trend was 0.0028.<h4>Conclusions</h4>Our findings suggested that vitamin D was related to zBMI negatively in Chinese preschoolers and maintaining adequate vitamin D levels may only contribute to lower the zBMI in preschoolers with low and intermediate genetic susceptibility.2024-01-01T00:00:00Z2024 Mar2026-04-08T15:10:37.578Z2025-04-05T23:16:05.37ZS-EPMC109751083854270310.3390/nu16060792