{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Plans-Rubio P"],"funding":["Instituto de Salud Carlos III"],"pagination":["54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10975791"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["The aim of this study was to identify factors associated with non-adherence to tuberculosis (TB) preventive treatment among contacts with latent TB infection for new cases of pulmonary TB cases reported in Catalonia in 2019-2021. All contacts aged 18 years or older with a latent TB infection who received a TB preventive treatment were included in the study. The Chi square test and the odds ratios (OR) were used to assess the association between non-adherence to TB preventive treatment and the study variables; a <i>p</i> < 0.05 was considered statistically significant. Multiple logistic regression analysis was used to detect the independent factors associated with TB preventive treatment non-adherence; a <i>p</i> < 0.05 was considered statistically significant. The percentage of non-adherence to TB preventive treatment found in this study was 23.7%. A multivariable logistic regression analysis determined that the following factors were significantly associated with TB preventive treatment non-adherence among adult contacts: \"exposure at school or workplace\" (aOR = 3.34), \"exposure to an index case without laboratory confirmation of TB\" (aOR = 2.07), \"immigrant contact\" (aOR = 1.81), \"male gender\" (aOR = 1.75) and \"exposure duration < 6 h per week or sporadic\" (aOR = 1.60. By contrast, the factor \"short-term TB preventive treatment regimen\" (aOR = 0.38) was significantly associated with a lower treatment non-adherence. Adherence to TB preventive treatment should be improved among adult contacts of TB pulmonary cases with latent TB infection by recommending short-term treatment regimens and by developing health education activities, with a greater focus on contacts with factors associated with treatment non-adherence."],"journal":["Tropical medicine and infectious disease"],"pubmed_title":["Factors Associated with Non-Adherence to Tuberculosis Preventive Treatment among Adult Contacts of Pulmonary Tuberculosis Cases with Latent Tuberculosis Infection in Catalonia, Spain, in 2019-2021."],"pmcid":["PMC10975791"],"funding_grant_id":["PI18/01751"],"pubmed_authors":["Godoy S","Toledo D","Parron I","Cayla J","Millet JP","Plans-Rubio P","Dominguez A","Godoy P"],"additional_accession":[]},"is_claimable":false,"name":"Factors Associated with Non-Adherence to Tuberculosis Preventive Treatment among Adult Contacts of Pulmonary Tuberculosis Cases with Latent Tuberculosis Infection in Catalonia, Spain, in 2019-2021.","description":"The aim of this study was to identify factors associated with non-adherence to tuberculosis (TB) preventive treatment among contacts with latent TB infection for new cases of pulmonary TB cases reported in Catalonia in 2019-2021. All contacts aged 18 years or older with a latent TB infection who received a TB preventive treatment were included in the study. The Chi square test and the odds ratios (OR) were used to assess the association between non-adherence to TB preventive treatment and the study variables; a <i>p</i> < 0.05 was considered statistically significant. Multiple logistic regression analysis was used to detect the independent factors associated with TB preventive treatment non-adherence; a <i>p</i> < 0.05 was considered statistically significant. The percentage of non-adherence to TB preventive treatment found in this study was 23.7%. A multivariable logistic regression analysis determined that the following factors were significantly associated with TB preventive treatment non-adherence among adult contacts: \"exposure at school or workplace\" (aOR = 3.34), \"exposure to an index case without laboratory confirmation of TB\" (aOR = 2.07), \"immigrant contact\" (aOR = 1.81), \"male gender\" (aOR = 1.75) and \"exposure duration < 6 h per week or sporadic\" (aOR = 1.60. By contrast, the factor \"short-term TB preventive treatment regimen\" (aOR = 0.38) was significantly associated with a lower treatment non-adherence. Adherence to TB preventive treatment should be improved among adult contacts of TB pulmonary cases with latent TB infection by recommending short-term treatment regimens and by developing health education activities, with a greater focus on contacts with factors associated with treatment non-adherence.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-26T11:23:48.441Z","creation":"2025-04-06T13:41:54.766Z"},"accession":"S-EPMC10975791","cross_references":{"pubmed":["38535878"],"doi":["10.3390/tropicalmed9030054"]}}