{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Taychaworaditsakul W"],"funding":["the Agricultural Research Development Agency (Public Organization) of Thailand"],"pagination":["198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10975813"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["<i>Carica papaya L.</i> leaves, traditionally utilized in dietary supplements and pharmaceuticals, exhibit a broad spectrum of potentially therapeutic properties, including anti-inflammatory, antimalarial, and wound healing properties. This study examined the acute and chronic toxicity of 10% ethanolic-extracted <i>C. papaya</i> leaf in Sprague Dawley rats. The acute toxicity assessment was a single oral dose of 5000 mg/kg body weight, while the chronic toxicity assessment included daily oral doses of 100, 400, 1000, and 5000 mg/kg over 180 days. Systematic monitoring covered a range of physiological and behavioral parameters, including body and organ weights. End-point evaluations encompassed hematological and biochemical analyses, along with gross and histopathological examinations of internal organs. Findings revealed no acute toxicity in the <i>C. papaya</i> leaf extract group, although a significant decrease in uterine weight was observed without accompanying histopathology abnormalities. In the chronic toxicity assessment, no statistically significant differences between the control and the <i>C. papaya</i> leaf extract groups were detected across multiple measures, including behavioral, physiological, and hematological indices. Importantly, histopathological examination corroborated the absence of any tissue abnormalities. The study results indicate that <i>C. papaya</i> leaf extract exhibited no adverse effects on the rats during the 180-day oral administration period, affirming its potential safety for prolonged usage."],"journal":["Toxics"],"pubmed_title":["Safety of Oral <i>Carica papaya</i> L. Leaf 10% Ethanolic Extract for Acute and Chronic Toxicity Tests in Sprague Dawley Rats."],"pmcid":["PMC10975813"],"funding_grant_id":["CRP6405030440"],"pubmed_authors":["Sireeratawong S","Taychaworaditsakul W","Saenjum C","Jaijoy K","Na Takuathung M","Lumjuan N","Chawansuntati K","Sawong S"],"additional_accession":[]},"is_claimable":false,"name":"Safety of Oral <i>Carica papaya</i> L. Leaf 10% Ethanolic Extract for Acute and Chronic Toxicity Tests in Sprague Dawley Rats.","description":"<i>Carica papaya L.</i> leaves, traditionally utilized in dietary supplements and pharmaceuticals, exhibit a broad spectrum of potentially therapeutic properties, including anti-inflammatory, antimalarial, and wound healing properties. This study examined the acute and chronic toxicity of 10% ethanolic-extracted <i>C. papaya</i> leaf in Sprague Dawley rats. The acute toxicity assessment was a single oral dose of 5000 mg/kg body weight, while the chronic toxicity assessment included daily oral doses of 100, 400, 1000, and 5000 mg/kg over 180 days. Systematic monitoring covered a range of physiological and behavioral parameters, including body and organ weights. End-point evaluations encompassed hematological and biochemical analyses, along with gross and histopathological examinations of internal organs. Findings revealed no acute toxicity in the <i>C. papaya</i> leaf extract group, although a significant decrease in uterine weight was observed without accompanying histopathology abnormalities. In the chronic toxicity assessment, no statistically significant differences between the control and the <i>C. papaya</i> leaf extract groups were detected across multiple measures, including behavioral, physiological, and hematological indices. Importantly, histopathological examination corroborated the absence of any tissue abnormalities. The study results indicate that <i>C. papaya</i> leaf extract exhibited no adverse effects on the rats during the 180-day oral administration period, affirming its potential safety for prolonged usage.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-26T11:28:51.867Z","creation":"2025-04-06T13:40:26.076Z"},"accession":"S-EPMC10975813","cross_references":{"pubmed":["38535931"],"doi":["10.3390/toxics12030198"]}}