{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khalaj M"],"funding":["University of Cologne"],"pagination":["1223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10976190"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(6)"],"pubmed_abstract":["Two previously described Brønsted acidic ionic liquids, 3,3'-(1,6-hexanediyl)bis(1-methyl)-1<i>H</i>-imidazolium hydrogen sulfate (<b>Cat1</b>) and 1,1'-(1,6-hexanediyl)bis(pyridinium) hydrogen sulfate (<b>Cat2</b>), were used as catalysts for the preparation of spiro[furan-2,3'-indoline]-3-carboxylate derivatives via a three-component reaction of anilines, isatins (<i>N</i>-alkyl-indoline-2,3-diones), and diethyl acetylenedicarboxylate, in high yields. The use of ultrasonic (US) irradiation led to the targeted products (<b>1a</b>-<b>15a</b>) in high yields ranging from 80% to 98%. Under the same conditions, the use of sulfuric acid and acetic acid as a Brønstedt catalyst did not yield the desired benchmark product <b>1a</b>."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Multi-Component Syntheses of Spiro[furan-2,3'-indoline]-3-carboxylate Derivatives Using Ionic Liquid Catalysts."],"pmcid":["PMC10976190"],"funding_grant_id":["Axel Klein"],"pubmed_authors":["Zarandi M","Musavi SM","Klein A","Khalaj M","Hohnsen J","Samadi Kazemi M"],"additional_accession":[]},"is_claimable":false,"name":"Multi-Component Syntheses of Spiro[furan-2,3'-indoline]-3-carboxylate Derivatives Using Ionic Liquid Catalysts.","description":"Two previously described Brønsted acidic ionic liquids, 3,3'-(1,6-hexanediyl)bis(1-methyl)-1<i>H</i>-imidazolium hydrogen sulfate (<b>Cat1</b>) and 1,1'-(1,6-hexanediyl)bis(pyridinium) hydrogen sulfate (<b>Cat2</b>), were used as catalysts for the preparation of spiro[furan-2,3'-indoline]-3-carboxylate derivatives via a three-component reaction of anilines, isatins (<i>N</i>-alkyl-indoline-2,3-diones), and diethyl acetylenedicarboxylate, in high yields. The use of ultrasonic (US) irradiation led to the targeted products (<b>1a</b>-<b>15a</b>) in high yields ranging from 80% to 98%. Under the same conditions, the use of sulfuric acid and acetic acid as a Brønstedt catalyst did not yield the desired benchmark product <b>1a</b>.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-26T11:22:26.313Z","creation":"2025-04-06T13:39:03.125Z"},"accession":"S-EPMC10976190","cross_references":{"pubmed":["38542860"],"doi":["10.3390/molecules29061223"]}}