{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Q"],"funding":["Science and Technology Planning Project of Guangdong Province","China Postdoctoral Science Foundation","National Natural Science Foundation of China","Provincial Major Scientific Research Projects at Universities of Guangdong Province"],"pagination":["1081-1096"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10976599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(3)"],"pubmed_abstract":["Lysosome-targeted photodynamic therapy, which enhances reactive oxygen species (ROS)-responsive tumor cell death, has emerged as a promising strategy for cancer treatment. Herein, a uridine (dU)-modified Ru(II) complex (RdU) was synthesized by click chemistry. It was found that RdU exhibits impressive photo-induced inhibition against the growth of triple-negative breast cancer (TNBC) cells in normoxic and hypoxic microenvironments through ROS production. It was further revealed that RdU induces ferroptosis of MDA-MB-231 cells under light irradiation (650 nm, 300 mW/cm<sup>2</sup>). Additional experiments showed that RdU binds to lysosomal integral membrane protein 2 (LIMP-2), which was confirmed by the fact that RdU selectively localizes in the lysosomes of MDA-MB-231 cells and significant"],"journal":["JACS Au"],"pubmed_title":["Uridine-Modified Ruthenium(II) Complex as Lysosomal LIMP-2 Targeting Photodynamic Therapy Photosensitizer for the Treatment of Triple-Negative Breast Cancer."],"pmcid":["PMC10976599"],"funding_grant_id":["2017M610576","2014KZDXM053","81572926","2014A020212312","81703349"],"pubmed_authors":["Li G","Yuan C","Mei W","Wu Q","Wang J","Li L","Wang Z","Zhu C","Lv Q"],"additional_accession":[]},"is_claimable":false,"name":"Uridine-Modified Ruthenium(II) Complex as Lysosomal LIMP-2 Targeting Photodynamic Therapy Photosensitizer for the Treatment of Triple-Negative Breast Cancer.","description":"Lysosome-targeted photodynamic therapy, which enhances reactive oxygen species (ROS)-responsive tumor cell death, has emerged as a promising strategy for cancer treatment. Herein, a uridine (dU)-modified Ru(II) complex (RdU) was synthesized by click chemistry. It was found that RdU exhibits impressive photo-induced inhibition against the growth of triple-negative breast cancer (TNBC) cells in normoxic and hypoxic microenvironments through ROS production. It was further revealed that RdU induces ferroptosis of MDA-MB-231 cells under light irradiation (650 nm, 300 mW/cm<sup>2</sup>). Additional experiments showed that RdU binds to lysosomal integral membrane protein 2 (LIMP-2), which was confirmed by the fact that RdU selectively localizes in the lysosomes of MDA-MB-231 cells and significant","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-19T10:14:48.946Z","creation":"2025-04-19T10:14:48.946Z"},"accession":"S-EPMC10976599","cross_references":{"pubmed":["38559730"],"doi":["10.1021/jacsau.3c00808"]}}