biostudies-literatureUnknown16(1)Feng N<h4>Background</h4>Epidemiological evidence has confirmed that periodontitis is an essential and independent risk factor of chronic obstructive pulmonary disease (COPD). <i>Porphyromonas gingivalis</i>, a major pathogen implicated in periodontitis, may make a vital contribution to COPD progression. However, the specific effects and molecular mechanism of the link between <i>P. gingivalis</i> and COPD are not clear.<h4>Methods and results</h4>A COPD rat model was constructed by smoke exposure combined intratracheal instillation of E. coli-LPS, then <i>P. gingivalis</i> was introduced into the oral cavity of COPD rats. This research observed that lower lung function, more severe alveolar damage and inflammation occurred in COPD rats with <i>P. gingivalis</i> group. Meanwhile, P. gingivalis/gJournal of oral microbiology2334588https://www.ebi.ac.uk/biostudies/studies/S-EPMC10977012biostudies-literature<i>P. gingivalis</i> alters lung microbiota and aggravates disease severity of COPD rats by up-regulating Hsp90α/MLKL.PMC10977012Feng NTan LPan YPeng DPan CGeng FHan XLi QWang Hfalse<i>P. gingivalis</i> alters lung microbiota and aggravates disease severity of COPD rats by up-regulating Hsp90α/MLKL.<h4>Background</h4>Epidemiological evidence has confirmed that periodontitis is an essential and independent risk factor of chronic obstructive pulmonary disease (COPD). <i>Porphyromonas gingivalis</i>, a major pathogen implicated in periodontitis, may make a vital contribution to COPD progression. However, the specific effects and molecular mechanism of the link between <i>P. gingivalis</i> and COPD are not clear.<h4>Methods and results</h4>A COPD rat model was constructed by smoke exposure combined intratracheal instillation of E. coli-LPS, then <i>P. gingivalis</i> was introduced into the oral cavity of COPD rats. This research observed that lower lung function, more severe alveolar damage and inflammation occurred in COPD rats with <i>P. gingivalis</i> group. Meanwhile, P. gingivalis/g2024-01-01T00:00:00Z20242025-04-26T11:21:59.632Z2025-04-06T13:40:22.606ZS-EPMC109770123855065910.1080/20002297.2024.2334588