{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma X"],"funding":["China Scholarship Council"],"pagination":["1304325"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10977602"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["Microbial population heterogeneity leads to different stress responses and growth behavior of individual cells in a population. Previously, a point mutation in the <i>rpsU</i> gene (<i>rpsU</i><sup>G50C</sup>) encoding ribosomal protein S21 was identified in a <i>Listeria monocytogenes</i> LO28 variant, which leads to increased multi-stress resistance and a reduced maximum specific growth rate. However, the underlying mechanisms of these phenotypic changes remain unknown. In <i>L. monocytogenes</i>, the alternative sigma factor SigB regulates the general stress response, with its activation controlled by a series of Rsb proteins, including RsbR1 and anti-sigma factor RsbW and its antagonist RsbV. We combined a phenotype and proteomics approach to investigate the acid and heat stress resist"],"journal":["Frontiers in microbiology"],"pubmed_title":["A single point mutation in the <i>Listeria monocytogenes</i> ribosomal gene <i>rpsU</i> enables SigB activation independently of the stressosome and the anti-sigma factor antagonist RsbV."],"pmcid":["PMC10977602"],"funding_grant_id":["201907720086"],"pubmed_authors":["Zwietering MH","Boeren S","Ma X","O'Byrne CP","Abee T","Tempelaars MH","den Besten HMW"],"additional_accession":[]},"is_claimable":false,"name":"A single point mutation in the <i>Listeria monocytogenes</i> ribosomal gene <i>rpsU</i> enables SigB activation independently of the stressosome and the anti-sigma factor antagonist RsbV.","description":"Microbial population heterogeneity leads to different stress responses and growth behavior of individual cells in a population. Previously, a point mutation in the <i>rpsU</i> gene (<i>rpsU</i><sup>G50C</sup>) encoding ribosomal protein S21 was identified in a <i>Listeria monocytogenes</i> LO28 variant, which leads to increased multi-stress resistance and a reduced maximum specific growth rate. However, the underlying mechanisms of these phenotypic changes remain unknown. In <i>L. monocytogenes</i>, the alternative sigma factor SigB regulates the general stress response, with its activation controlled by a series of Rsb proteins, including RsbR1 and anti-sigma factor RsbW and its antagonist RsbV. We combined a phenotype and proteomics approach to investigate the acid and heat stress resist","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-05-29T10:05:07.937Z","creation":"2024-11-20T08:41:17.818Z"},"accession":"S-EPMC10977602","cross_references":{"pubmed":["38550865"],"doi":["10.3389/fmicb.2024.1304325"]}}